摘要
目的探讨脑卒中后抑郁症(PSD)患者采用重复经颅磁刺激联合文拉法辛治疗的效果.方法选择2020年4月—2022年6月本院收治的78例PSD患者为研究对象,按随机数字表法分为两组,每组39例.对照组采用文拉法辛治疗,观察组采用文拉法辛联合重复经颅磁刺激治疗,均持续治疗4周.对比两组患者的负性情绪、神经功能、日常生活能力及不良反应发生情况.结果观察组治疗后的焦虑自评量表、抑郁自评量表评分分别为(44.03±2.93)分、(46.10±3.26)分,均低于对照组的(47.46±3.17)分、(49.12±3.71)分,组间差异有统计学意义(P<0.05).观察组治疗后的美国国家卫生研究院卒中量表评分为(24.28±3.77)分,低于对照组的(30.15±4.06)分,日常生活能力指数量表评分为(73.79±5.81)分,高于对照组的(66.63±5.74)分,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论重复经颅磁刺激联合文拉法辛能够减轻PSD患者的负性情绪,改善其神经功能,提升日常生活能力,且不会增加不良反应,具有较好的应用安全性.
Objective To investigate the effect of repetitive transcranial magnetic stimulation combined with venlafaxine in patients with post-stroke depression(PSD).Methods 78 PSD patients admitted to the hospital from April 2020 to June 2022 were selected as the research objects and were divided into two groups according to random number table method,with 39 cases in each group.The control group was treated with venlafaxine,and the observation group was treated with venlafaxine combined with repetitive transcranial magnetic stimulation.Both groups were treated for 4 weeks.The negative emotions,neurological function,daily living ability and adverse reactions were compared between the two groups.Results The scores of self-rating anxiety scale and self-rating depression scale after treatment in the observation group were(44.03±2.93)points and(46.10±3.26)points,respectively,which were lower than(47.46±3.17)points and(49.12±3.71)points in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the National Institutes of Health stroke scale score in the observation group was(24.28±3.77)points,lower than(30.15±4.06)points in the control group,and the daily living ability score was(73.79±5.81)points,higher than(66.63±5.74)points in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Repetitive transcranial magnetic stimulation combined with venlafaxine can alleviate negative emotions,improve neurological function and enhance daily living ability in PSD patients without increasing adverse reactions,and has a good application safety.
作者
王节强
李召泉
房蕾
WANG Jieqiang;LI Zhaoquan;FANG Lei(Department of Rehabilitation Medicine,Shandong Zaozhuang Mental Health Center,Zaozhuang Shandong,277100,China)
出处
《反射疗法与康复医学》
2023年第8期56-58,共3页
Reflexology And Rehabilitation Medicine
关键词
重复经颅磁刺激
脑卒中后抑郁症
文拉法辛
负性情绪
日常生活能力
神经功能
Post-Stroke depression
Repetitive transcranial magnetic stimulation
Venlafaxine
Negative emotions
Daily living ability
Neurological function
作者简介
王节强(1974-),男,山东菏泽人,本科,副主任医师,研究方向:康复医学。
