摘要
目的探究与分析葛根芩连汤治疗湿热阻络型糖尿病周围神经病变患者的效果。方法选取山东省聊城市中医医院2019年1月至2021年1月收治的湿热阻络型糖尿病周围神经病变患者120例,采取随机数字表法分为对照组与观察组,每组各60例。对照组给予前列腺素E1和甲钴胺治疗,观察组在对照组的基础上加用葛根芩连汤治疗,两组均连续治疗1个月。比较两组临床疗效,比较两组治疗前后血糖水平、肠道菌群含量、神经传导速度及神经病变主觉症状问卷(TSS)评分,同时观察治疗期间的不良反应。结果观察组临床总有效率高于对照组(P<0.05)。治疗后两组空腹血糖、空腹胰岛素及糖化血红蛋白较治疗前降低,且观察组低于对照组(P<0.05)。治疗后两组梭状芽孢杆菌属菌群含量较治疗前升高,且观察组高于对照组;拟杆菌属菌群含量较治疗前降低,且观察组低于对照组(P<0.05)。治疗后两组运动传导速度、感觉传导速度较治疗前升高,且观察组高于对照组(P<0.05)。治疗后两组TSS评分较治疗前降低,且观察组低于对照组(P<0.05)。两组治疗期间均未出现严重不良反应。结论葛根芩连汤治疗湿热阻络型糖尿病周围神经病变患者可有效地改善患者临床症状及体征,调节血糖指标,改善肠道菌群含量,且治疗期间无严重不良反应,安全性有保障。
Objective To explore and analyze the effect of Gegen Qinlian Decoction in the treatment of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals.Methods A total of 120 diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals were selected from Liaocheng Hospital of Traditional Chinese Medicine,Shandong Province from January 2019 to January 2021.They were divided into control group and observation group by random number table method,with 60 cases in each group.The control group was given Prostaglandin E1 and Methylcobalamin,observation group was given Gegen Qinlian Decoction on the basis of control group,both groups were treated continuously for one month.The clinical efficacy in both groups was compared,the blood glucose levels,intestinal flora content,nerve conduction velocity,and total symptoms score before and after treatment were compared between two groups,while adverse reactions during treatment were observed.Results The total clinical effective rate in observation group was higher than that in the control group(P<0.05).After treatment,fasting blood glucose,fasting insulin,and glycosylated hemoglobin in the two groups were lower than those before treatment,and which in the observation group were lower than those in the control group(P<0.05).After treatment,the content of Clostridium flora in the two groups was higher than that before treatment,and the observation group was higher than that in the control group;the content of Bacteroids flora in observation group was lower than that in the control group(P<0.05).After treatment,the motor conduction velocity and sensory conduction velocity of the two groups were higher than those before treatment,and which in the observation group were higher than those in the control group(P<0.05).TSS scores of the two groups after treatment were lower than those before treatment,and the observation group was lower than that in the control group(P<0.05).There were no serious adverse reactions in two groups during treatment.Conclusion Gegen Qinlian Decoction can effectively improve the clinical symptoms and signs of diabetic peripheral neuropathy patients with syndrome of dampness and heat obstructing collaterals,regulate blood glucose levels,improve the content of intestinal flora,and there are no serious adverse reactions during treatment,the safety is guaranteed.
作者
郑晓东
冯燕
韩磊
ZHENG Xiaodong;FENG Yan;HAN Lei(Department of Endocrinology,Liaocheng Traditional Chinese Medicine Hospital,Shandong Province,Liaocheng252000,China;Operating Room,Liaocheng Traditional Chinese Medicine Hospital,Shandong Province,Liaocheng252000,China;Department of Laboratory,Liaocheng Traditional Chinese Medicine Hospital,Shandong Province,Liaocheng252000,China)
出处
《中国医药导报》
CAS
2022年第12期61-65,共5页
China Medical Herald
基金
全国中医临床特色技术传承骨干人才培训项目(国中医药人教函〔2019〕36号)。
关键词
肠道菌群
葛根芩连汤
湿热阻络型
糖尿病周围神经病变
血糖
不良反应
Intestinal flora
Gegen Qinlian Decoction
Syndrome of dampness and heat obstructing collaterals
Diabetic peripheral neuropathy
Blood glucose
Adverse reactions
作者简介
郑晓东(1980.3-),男,硕士,副主任医师,研究方向:中医药防治内分泌代谢疾病。
