摘要
目的评估不稳定型心绞痛患者应用低分子肝素钙治疗的效果。方法82例不稳定型心绞痛患者,根据随机数字表法分为对照组与观察组,各41例。对照组行常规治疗,观察组行低分子肝素钙治疗。比较两组患者的心绞痛发作情况和心电图检查结果,实验室指标[凝血酶时间(TT)、凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)]。结果治疗前,两组患者心绞痛发作次数、心绞痛发作持续时间、T波倒置深度、T波倒置联数比较,差异无统计学意义(P>0.05);治疗后,观察组心绞痛发作次数(3.45±0.58)次/d、T波倒置深度(1.38±0.75)mV和T波倒置联数(1.25±0.69)个均小于对照组的(4.89±0.75)次/d、(2.32±0.86)mV、(2.19±0.63)个,心绞痛发作持续时间(1.72±0.63)min/次短于对照组的(2.64±0.58)min/次,差异具有统计学意义(P<0.05)。治疗前,两组患者TT、PT和APTT比较,差异无统计学意义(P>0.05);治疗后,观察组患者的TT(17.69±0.52)s、PT(14.88±1.25)s和APTT(37.89±1.88)s均长于对照组的(16.02±0.63)、(12.63±1.57)、(34.15±2.02)s,差异具有统计学意义(P<0.05)。结论不稳定型心绞痛患者应用低分子肝素钙治疗可以获得显著成效,值得在临床上使用和推广。
Objective To evaluate the effect of low molecular weight heparin calcium in the treatment of unstable angina pectoris.Methods A total of 82 patients with unstable angina pectoris were divided into control group and observation group according to random numerical table,with 41 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with low molecular weight heparin calcium.The angina attack and electrocardiogram results,laboratory indicators[thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)]were compared between the two groups.Results Before treatment,there was no statistically significant difference in the number of angina attacks,duration of angina attacks,depth of T-wave inversion,and number of T-wave inversions between the two groups(P>0.05).After treatment,the number of angina attacks(3.45±0.58)attacks/d,depth of T-wave inversion(1.38±0.75)mV and number of T-wave inversions(1.25±0.69)in the observation group were less than(4.89±0.75)attacks/d,(2.32±0.86)mV and(2.19±0.63)in the control group,and the duration of angina attacks(1.72±0.63)min/time was shorter than(2.64±0.58)min/time in the control group.All the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in TT,PT and APTT between the two groups(P>0.05).After treatment,the TT(17.69±0.52)s,PT(14.88±1.25)s and APTT(37.89±1.88)s of the observation group were longer than(16.02±0.63),(12.63±1.57)and(34.15±2.02)s of the control group,and the differences were statistically significant(P<0.05).Conclusion The application of low molecular weight heparin calcium in patients with unstable angina pectoris can achieve significant results,and is worthy of clinical use and promotion.
作者
陶帅
TAO Shuai(Fuxin Second People’s Hospital(Fuxin Obstetrics and Gynecology Hospital),Fuxin 123000,China)
出处
《中国现代药物应用》
2022年第6期96-98,共3页
Chinese Journal of Modern Drug Application
关键词
不稳定型心绞痛
低分子肝素钙
疗效
Unstable angina pectoris
Low molecular weight heparin calcium
Efficacy
