摘要
目的对比卡马西平、托吡酯对缺血性脑卒中合并继发性癫痫患者血清氧化应激指标及预后的影响。方法选取睢县中医院2018年1月至2019年2月收治的60例缺血性脑卒中合并继发性癫痫患者为研究对象,采用随机分组法将其分为A组(30例)和B组(30例)。在常规治疗的基础上,给予A组患者卡马西平治疗,给予B组患者托吡酯治疗,两组患者治疗时间均为6个月。比较两组患者的疗效、神经功能、日常活动能力、认知功能、血清氧化应激指标[丙二醛(MDA)、8-羟基脱氧鸟苷酸(8-OHdG)、谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)]、不良反应以及生活质量。结果治疗后B组患者的有效率高于A组患者,差异有统计学意义(P<0.05)。治疗后B组血清8-OHdG、MDA水平均明显低于A组,GSH-Px、SOD水平均明显高于A组,差异有统计学意义(P<0.05)。治疗后B组患者神经功能缺损评分及不良反应发生率明显低于A组、认知能力评分及日常活动能力评分明显高于A组,差异有统计学意义(P<0.05)。治疗后B组患者的生活质量评分高于A组,差异有统计学意义(P<0.05)。结论托吡酯治疗缺血性脑卒中合并继发性癫痫效果优于卡马西平,对于改善患者的血清氧化应激指标的效果更明显,且患者预后更佳。
Objective To compare the effects of carbamazepine and topiramate on serum oxidative stress index and prognosis of ischemic stroke patients with secondary epilepsy.Methods A total of 60 patients with ischemic stroke complicated with secondary epilepsy in Sui County Hospital of Traditional Chinese Medicine from January 2018 to February 2019 were selected as the research objects,and they were divided into group A(30 cases)and group B(30 cases)by random grouping method.On the basis of conventional treatment,patients in group A were given carbamazepine and patients in group B were given topiramate for 6 months in both groups.The efficacy,neurological function,daily activity ability,cognitive function,serum oxidative stress indexes[MALondialdehyde(MDA),8-hydroxydeoxyguanylate(8-OHDG),glutathione peroxidase(GSH-PX)and superoxide dismutase(SOD)],adverse reactions and quality of life of 2 groups were compared.Results After treatment,the effective rate of group B was higher than that of group A,the difference was statistically significant(P<0.05).After treatment,the levels of serum 8-OHDG and MDA in group B were significantly lower than those in group A,and the levels of GSH-Px and SOD were significantly higher than those in group A,with statistical significance(P<0.05).After treatment,the neurological deficit score and the incidence of adverse reactions in group B were significantly lower than those in group A,and the cognitive ability score and daily activity ability score were significantly higher than those in group A,with statistical significance(P<0.05).After treatment,the quality of life score of group B was higher than that of group A,the difference was statistically significant(P<0.05).Conclusion Topiramate is superior to carbamazepine in the treatment of ischemic stroke complicated with secondary epilepsy,and has a more obvious effect on improving the serum oxidative stress index of patients,and the prognosis of patients is better.
作者
常艳艳
CHANG Yanyan(Department of Neurology,Sui County Hospital of Traditional Chinese Medicine,Shangqiu Henan 476900,China)
出处
《临床研究》
2022年第5期80-84,共5页
Clinical Research
关键词
继发性癫痫
卡马西平
托吡酯
血清氧化应激指标
secondary epilepsy
carbamazepine
topiramate
serum oxidative stress markers
作者简介
常艳艳(1987-),女,汉族,河南商丘人,主治医师,本科。研究方向:神经重症医学方向。
