摘要
目的探讨托吡酯治疗脑梗死继发性癫痫的临床疗效,及其对患者认知功能的影响。方法选取山东高唐县人民医院2018年3月至2019年3月收治的160例脑梗死继发性癫痫患者,随机分为常规组和研究组,每组80例。常规组接受卡马西平治疗,研究组接受托吡酯治疗,均连续治疗6个月。治疗前后,使用美国国立卫生研究院卒中量表(NHISS)评估并比较两组患者的神经损伤程度,采用蒙特利尔认知评估量表(MoCA)评估并比较两组患者的认知情况,采用生活质量评定量表(SF-36)评估并比较两组患者生活质量水平;观察并比较两组患者的临床治疗效果和不良反应发生情况。结果治疗后,研究组NHISS评分低于本组治疗前和同期对照组,差异均有统计学意义(P<0.05)。治疗后,研究组MoCA评分高于本组治疗前和同期对照组,差异均有统计学意义(P<0.05)。研究组治疗总有效率(98.75%),高于常规组(63.75%),差异有统计学意义(P<0.05)。治疗后,研究组生活质量评分高于本组治疗前和同期对照组,差异均有统计学意义(P<0.05)。研究组不良反应总发生率(5.00%),低于常规组(12.50%),差异有统计学意义(P<0.05)。结论托吡酯能有效治疗脑梗死后的癫痫,有利于改善认知功能,同时提升患者的生活质量,促进患者恢复。
Objective To investigate the clinical efficacy of topiramate in the treatment of secondary epilepsy of cerebral infarction and its effect on patients’cognitive function.Methods A total of 160 patients with secondary epilepsy of cerebral infarction who were treated in Shandong Gaotang County People’s Hospital from March 2018 to March 2019 were randomly divided into the routine group and the study group,with 80 cases in each group.The routine group received carbamazepine,and the study group received topiramate,and both groups were treated continuously for 6 months.Before and after treatment,the National Institutes of Health Stroke Scale(NHISS)was used to evaluate the patients’degree of neurological damage;the Montreal Cognitive Assessment Scale(MoCA)was used to evaluate the patients’cognitive status;the rating scale(SF-36)was used to evaluate the patients’quality of life.The clinical treatment effects and adverse reactions of the two groups were observed and compared.Results After treatment,the NHISS score of the study group was lower than that of the routine group;the MoCA score of the study group was higher than that of the routine group.The differences were statistically significant(P<0.05).The total effective rate of treatment in the study group(98.75%)was higher than that in the routine group(63.75%),and the difference was statistically significant(P<0.05).After treatment,the quality of life score in the study group was higher than that in the routine group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group(5.0%)was lower than that in the routine group(12.5%),and the difference was statistically significant(P<0.05).Conclusion Topiramate can effectively treat epilepsy after cerebral infarction,which is beneficial to improve cognitive function,at the same time improve the quality of life of patients,and promote recovery of patients.
作者
鞠吉静
JU Ji-jing(Shandong Gaotang County People’s Hospital,Liaocheng 252800,Shandong,China)
出处
《慢性病学杂志》
2020年第1期18-20,23,共4页
Chronic Pathematology Journal
关键词
托吡酯
脑梗死
癫痫
临床效果
认知功能
Topiramate
Cerebral infarction
Epilepsy
Clinical efficacy
Cognitive function
作者简介
通信作者:鞠吉静,硕士研究生,主治医师,研究方向:治疗脑梗死,E-mail:jujijing1031@sina.com
