摘要
目的研究年轻乳腺癌患者接受保乳手术后是否比非年轻乳腺癌患者有更高的局部复发率。方法计算机检索PubMed、EMBASE、中国知网、维普数据库、Google学术、万方数据库深圳市卫生健康电子文献共享平台等数据库,比较年轻乳腺癌患者(小于35~45岁)与非年轻乳腺癌患者(大于35~45岁)保乳术后局部复发率的临床对照研究。采用STATA 12.0软件对纳入研究进行Meta分析,对汇总后的相对危险系数(RR)及95%可信区间(CI)进行分析,并对纳入文献的发表偏倚进行分析。结果共纳入23项研究(共18775例患者)。总体分析,RR=2.639,95%CI:2.338~2.979,说明年轻乳腺癌组较非年轻乳腺癌组有更高的局部复发率,且结论差异有统计学意义;而对接受手术时的所在年份(以该时间段的最晚年份进行分组)进行亚组分析时发现,在2010年至2020年期间接受手术的患者,RR=1.348,95%CI:0.653~2.780,说明该时期的年轻组乳腺癌患者比非年轻组乳腺癌患者有更高的局部复发率,但差异无统计学意义。结论在近10年接受保乳手术的年轻乳腺癌患者,其术后局部复发率与非年轻乳腺癌患者相比差异无统计学意义,局部复发情况得到明显控制,治疗效果得到显著改善。故在目前的诊疗规范指导下,年龄较低并不增加乳腺癌患者保乳术后复发的风险,具有保乳指征的年轻乳腺癌患者,同样可以通过保乳手术,得到有效的治疗。
Objective To investigate whether young breast cancer patients undergoing breast-conserving surgery have a higher rate of local recurrence than non-young breast cancer patients.Methods PubMed,Embase,CNKI,VIP database,Google Scholar,Wanfang database,Shenzhen Health Electronic Literature Sharing Platform,and and other databases were searched by computer to compare the l the local recurrence rate after breast-preserving surgery between young breast cancer patients(less than 35~45 years old)and non-young breast cancer patients(more than 35~45 years old).Stata12.0 software was used for Meta-analysis of the included studies,the RR and 95%confidence interval(CI)were analyzed,as well as publication bias of the included literatures.Results A total of 23 studies(18,775 patients)were included.Overall analysis,RR=2.639,95%CI:2.338~2.979,indicating that young breast cancer group had a higher local recurrence rate than non-young breast cancer group,and the difference was statistically significant.For patients who underwent surgery from 2010 to 2020,RR=1.348,95%CI:0.653~2.780 indicating that young breast cancer patients in this period had a higher local recurrence rate than non-young breast cancer patients,but the difference was not statistically significant.Conclusion In recent 10 years,the local recurrence rate of young breast cancer patients who have received breast-conserving surgery has no statistical significance compared with non-young breast cancer patients,and the local recurrence has been significantly controlled,and the treatment effect has been significantly improved Therefore,under the guidance of current diagnosis and treatment norms,younger age does not increase the risk of recurrence of breast cancer patients after breast-conserving surgery.Young breast cancer patients with breast-conserving surgery can also receive effective treatment through breast-conserving surgery.
作者
赵光楠
王敏
王媛
曾圣光
严俊
郑爱秋
Zhao Guangnan;Wang Min;Wang Yuan;Zeng Shengguang;Yan Jun;Zheng Aiqiu(Department of Breast Surgery,Shenzhen Hospital,University of Hong Kong,Shenzhen Guangdong Province 518053,China)
出处
《中华普外科手术学杂志（电子版）》
2022年第2期166-171,共6页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
基金
广东省医学科研基金(B2021116)。
作者简介
通信作者:郑爱秋,Email:zhengq@hku-szh.org。
