摘要
目的:通过葛根芩连汤对初发2型糖尿病肠道湿热证的治疗,观察胰岛β细胞功能相关指标的变化,为中医药治疗该病提供客观依据。方法:本研究选取初发2型糖尿病肠道湿热证患者60例,随机分组,治疗组(30例)给予基础治疗联合葛根芩连汤治疗,对照组(30例)给予基础治疗联合二甲双胍治疗。观察治疗前后中医证候评分、身体质量指数、腰围、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、空腹血糖、餐后2小时血糖、胰岛素抵抗指数、胰岛素分泌指数的变化。结果:治疗前后对比,两组空腹血糖、餐后2小时血糖、糖化血红蛋白的差异有统计学意义(P<0.05,P<0.01);治疗后组间对比,对照组空腹血糖、糖化血红蛋白下降程度要好于治疗组(P<0.05),餐后2小时血糖的差异无统计学意义(P>0.05)。治疗前后对比,两组胰岛素抵抗指数的差异有统计学意义(P<0.05,P<0.01);治疗后两组胰岛素抵抗指数对比,对照组改善程度要好于治疗组(P<0.05)。两组胰岛素分泌指数治疗前后对比,差异无统计学意义(P>0.05)。治疗前后对比,治疗组三酰甘油的差异有统计学意义(P<0.05),对照组总胆固醇、低密度脂蛋白胆固醇的差异有统计学意义(P<0.05)。前后对比,治疗组中医证候评分的差异有统计学意义(P<0.05),对照组的差异无统计学意义(P>0.05)。两组腰围及身体质量指数治疗前后的差异有统计学意义(P<0.05,P<0.01);治疗后,对照组下降程度要好于治疗组(P<0.05)。结论:葛根芩连汤具有降低血糖、三酰甘油、腰围和身体质量指数,改善初诊2型糖尿病肠湿热证患者中医证候积分的作用,其降糖、降脂机制与改善胰岛素抵抗指数有关。
Objective:To observe the changes of islet β-cell function related indexes in treating intestinal damp heat syndrome of type 2 diabetes mellitus with the Gegen Qinlian decoction(葛根芩连汤),so as to provide objective basis for TCM treatment.Methods:60 cases were randomly divided into groups,the treatment group(30 cases)was treated by basic treatment plus the Gegen Qinlian decoction,and the control group(30 cases)was treated by basic treatment plus metformin.Results:Before and after treatment,the GLU,2 h PG and HbAlc in two groups were significantly different(P<0.05,P<0.01);after treatment,the decrease of GLU and HbAlc in the control group was better than the treatment group(P<0.05),but there was no significant difference in 2 h PG(P>0.05).Before and after treatment,HOMA-IR in two groups were significantly different(P<0.05,P<0.01);after treatment,the improvement of HOMA-IR in the control group was better than the treatment group(P<0.05).There was no significant difference between the two groups before and after treatment in insulin secretion index(P>0.05).Before and after treatment,TG in the treatment group was significantly different(P<0.05),TC and LDL-C in the control group were statistically different(P<0.05).Before and after treatment TCM syndrome score in the treatment group showed statistical difference(P<0.05),while the control group showed no statistical difference(P>0.05).Before and after treatment,waist circumference and BMI in two groups showed statistical difference(P<0.05,P<0.01);after treatment,the degree of decline in the control group was better than the treatment group(P<0.05).Conclusion:The Gegen Qinlian decoction can reduce blood glucose,triglyceride,waist circumference and body mass index,and ameliorate TCM syndrome score of patients with intestinal damp heat syndrome of type 2 diabetes mellitus,and its hypoglycemic and lipid-lowering mechanism was related to the improvement of HOMA-IR.
出处
《中医临床研究》
2022年第2期75-79,共5页
Clinical Journal Of Chinese Medicine
基金
2018年甘肃省中医药管理局科研项目(2018ZD04)。
关键词
Β细胞功能
肠道湿热证
2型糖尿病
葛根芩连汤
β-cell function
Intestinal damp heat syndrome
Type 2 diabetes mellitus
The Gegen Qinlian decoction
作者简介
康学东,主任医师,从事中西医结合防治糖尿病研究工作;通讯作者:任伯达,硕士研究生,从事中西医结合治疗糖尿病及其并发症研究工作。
