摘要
目的运用数据挖掘法探析中医治疗慢性胃炎伴焦虑障碍的用药规律。方法检索中国知网、万方、维普数据库中关于慢性胃炎伴焦虑障碍的文献,建立数据库,分析中医治疗慢性胃炎伴焦虑障碍的药物使用情况及其属性(包括四气、五味、归经)和药物配伍情况,并运用古今医案云平台V2.3系统进行聚类分析和复杂网络分析。结果纳入处方共31首,共计中药96味,处方中以柴胡的使用频次最多,其次是白芍。四气以温性药物的使用频次最高,其次是性微寒的中药;五味则以苦味药物的使用频次最多,其次为辛味;主归脾经,其次为肝经;最常用的药对为“白芍-柴胡”。使用频次位于前12的中药可分为4大类:第1类为以甘草、党参为主的益气健脾药物;第2类为以柴胡、白芍、茯苓、白术为主的理气健脾药物;第3类为以炙甘草、香附、枳壳为主的理气类药物;第4类为以法半夏、郁金、陈皮为主的燥湿理气药物。复杂网格分析显示核心药物组成为柴胡、香附、陈皮、白芍、白术、茯苓、炙甘草。结论慢性胃炎伴焦虑障碍的中医药治法以疏肝理气健脾为主,药物之间配伍的原则多以疏肝为法,兼以理气、健脾、和胃、止痛等,方药以柴胡疏肝散、四君子汤经典方剂为基础方。
Objective To explore the medication rules of traditional Chinese medicine(TCM)therapy for chronic gastritis with anxiety disorder using the data mining method.Methods The literature on chronic gastritis with anxiety disorder were searched in CNKI,Wanfang Data and VIP databases to establish a database for an analysis of the utilization of the drugs in TCM therapy for chronic gastritis with anxiety disorder and their properties(including four nature of drugs,five flavours,channel tropism),as well as Chinese drugs combination.In addition,the Ancient and Modern Medical Records Cloud Platform(Version 2.3)System was employed to perform a cluster analysis and a complex network analysis.Results A total of 31 prescriptions consisting of 96 Chinese drugs were collected,among which the most frequently used drug was Bupleuri Radix,followed by Paeoniae Radix Alba.From the perspective of the four nature of drugs,the most frequently used Chinese drugs were those with warm property,followed by those with a bit cold property;from the perspective of the five flavours,the most frequently used Chinese drugs were those with bitter flavour,followed by those with acrid flavour;the 96 Chinese drugs were mostly spleen meridian drugs,followed by the liver meridian drugs;and the most commonly-used Chinese drugs combination was"Paeoniae Radix Alba-Bupleuri Radix".The top 12 most frequently used Chinese drugs could be classified into four categories:Category 1 Chinese drugs were those for benefiting qi and invigorating spleen,which involved Glycyrrhizae Radix et Rhizoma and Codonopsis Radix;Category 2 Chinese drugs were those for regulating qi-flowing and invigorating spleen,which involved Bupleuri Radix,Paeoniae Radix Alba,Poria,and Atractylodis Macrocephalae Rhizoma;Category 3 Chinese drugs were those for regulating qi-flowing,which involved Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Cyperi Rhizoma,and Aurantii Fructus;and Category 4 Chinese drugs were those for eliminating dampness and regulating qi-flowing,which involved Pinelliae Rhizoma Praeparatum,Curcumae Radix,and Citri Reticulatae Pericarpium.The complex network analysis revealed that the core drugs comprised Bupleuri Radix,Cyperi Rhizoma,Citri Reticulatae Pericarpium,Paeoniae Radix Alba,Atractylodis Macrocephalae Rhizoma,Poria,and Glycyrrhizae Radix et Rhizoma Praeparata cum Melle.Conclusion TCM therapy for chronic gastritis with anxiety disorder mainly aims to disperse stagnated liver-qi and invigorate spleen,and the primary principle for Chinese drugs combination is with dispersing stagnated liver-qi as the law,taking the effects of regulating qi-flowing,invigorating spleen,harmonizing stomach and relieving pain as the auxiliary.Its essential prescriptions include canonical formulas such as Chaihu Shugan Powder and Sijunzi Decoction.
作者
韦赛艳
唐友明
姜枫
黎锵
WEI Sai-yan;TANG You-ming;JIANG Feng;LI Qiang(Graduate School,Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Gastroenterology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China)
出处
《广西医学》
CAS
2022年第2期125-128,共4页
Guangxi Medical Journal
基金
国家自然科学基金(81860843)。
关键词
慢性胃炎
焦虑障碍
数据挖掘
用药规律
Chronic gastritis
Anxiety disorder
Data mining
Medication rule
作者简介
韦赛艳(1991-),女,在读硕士研究生,研究方向:中西医结合治疗消化系统疾病,电子邮箱:893965685@qq.com;通信作者:唐友明(1964-),男,硕士,主任医师,研究方向:中西医结合治疗消化系统疾病,电子邮箱:905203532@qq.com。
