摘要
支气管肺发育不良(bronchopulmonary dysplasia,BPD)是早产儿常见的慢性呼吸系统疾病,其病死率高、存活患儿远期预后差,目前尚缺乏有效的干预手段。母乳喂养可降低BPD的发生率,这有赖于母乳中的多种生物活性物质,如免疫球蛋白、低聚糖、外泌体等。其中外泌体是细胞分泌的纳米样囊泡小体,参与细胞间的信息传递和功能调控,对机体亲和力高,可耐受胃肠道酶及胃酸的消化,并靶向于肺、肝脏等器官,有望成为BPD的防治新手段。
Bronchopulmonary dysplasia(BPD)is a common chronic respiratory disease,with high mortality and poor long-term prognosis in surviving children,and there is currently no effective intervention.Breastfeeding reduces the incidence of BPD.These depend on a variety of bioactive substances in human breast milk,such as immunoglobulins,oligosaccharides,exosomes,etc.Exosomes are nano-like vesicle bodies secreted by cells,which participate in information transmission and functional regulation between cells.They have high affinity for the body and can tolerate digestion of gastrointestinal enzymes and stomach acid.These enable them to target lung,liver and other organs smoothly.They are expected to become a new method for the prevention and treatment of BPD.
作者
刘林杰(综述)
余章斌(审校)
Liu Linjie;Yu Zhangbin(Department of Pediatrics,Maternity Hospital Affiliated to Nanjing Medical University(Nanjing Maternal and Child Health Hospital),Nanjing 210004,China)
出处
《国际儿科学杂志》
2022年第1期58-62,共5页
International Journal of Pediatrics
基金
国家自然科学基金(82001597)。
关键词
母乳
外泌体
支气管肺发育不良
早产儿
Human breast milk
Exosomes
Bronchopulmonary dysplasia
Premature infant
作者简介
通信作者:余章斌,Email:yuzhangbin@163.com。
