摘要
目的观察火针疗法联合308 nm准分子光治疗白癜风的临床疗效及对相关指标的影响。方法选择2019年7月—2020年12月在石家庄市中医院皮肤科门诊就诊的100例白癜风患者,按照随机平行分组法分为对照组与观察组各50例。对照组应用308 nm准分子光治疗,观察组应用火针疗法+308 nm准分子光治疗,2组均连续治疗8周。观察2组患者治疗前后皮损面积及血清转化生长因子-β(TGF-β)、白细胞介素-17(IL-17)、白细胞介素-25(IL-25)水平和皮肤病生活质量指数(DLQI)评分变化,比较2组治疗后临床疗效及不良反应发生情况。结果治疗4周、8周后2组皮损面积均呈现明显缩小趋势(P均<0.05),观察组各时间点皮损面积均明显小于对照组(P均<0.05)。治疗后2组TGF-β、IL-17、IL-25水平以及DLQI评分均较治疗前明显下降(P均<0.05),观察组各指标均明显低于对照组(P均<0.05);观察组治疗总有效率为90.0%(45/50),明显高于对照组的76.0%(38/50),差异有统计学意义(P<0.05);2组不良反应发生率组间比较差异无统计学意义(P>0.05)。结论火针疗法联合308 nm准分子光治疗白癜风不仅可明显缩小皮损面积,还可有效下调各炎性因子水平,提高患者生活质量。
Objective It is to observe the clinical efficacy of fire acupuncture combined with 308 nm excimer light in the treatment of vitiligo and its influence on related indicators. Methods One hundred patients with vitiligo who were treated in the Dermatology Outpatient Department of Shijiazhuang Hospital of Traditional Chinese Medicine From July 2019 to December 2020 were selected and randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with 308 nm excimer light, while the observation group was treated with fire needling therapy combined with 308 nm excimer light. Both groups were continuously treated for 8 weeks. The changes in skin lesion area, the levels of serum transforming factor(TGF-β), interleukin-17(IL-17), interleukin-25(IL-25) and Dermatology Life Quality Index(DLQI) before and after treatment were observed in the two groups, and the clinical efficacy and adverse reactions were compared between the two groups after treatment. Results After 4 weeks and 8 weeks of treatment, the area of skin lesions in the two groups showed a significant shrinking trend(P<0.05), and the area of skin lesions in the observation group was significantly smaller than that in the control group at each time point(all P<0.05). After treatment, the levels of TGF-β, IL-17, IL-25 and DLQI scores in the two groups were significantly lower than those before treatment(all P<0.05), and each index in the observation group was significantly lower than that in the control group(P<0.05);the total effective rate in the observation group was 90.0%(45/50), which was significantly higher than 76.0%(38/50) in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Fire acupuncture combined with 308 nm excimer light can not only significantly reduce the area of skin lesions, but also effectively down-regulate the levels of various inflammatory factors and improve the quality of life of patients in the treatment of vitiligo.
作者
邱洞仙
边莉
柴旭亚
师小萌
QIU Dongxian;BIAN Li;CHAI Xuya;SHI Xiaomeng(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,Hebei,China)
出处
《现代中西医结合杂志》
CAS
2022年第3期343-347,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河北省中医药管理局科研计划项目(2020324)。
作者简介
邱洞仙,女,硕士,主治医师,研究方向为皮肤病、性病的诊治。
