摘要
目的观察健脾补肾法治疗艾滋病患者的临床效果。方法选取2017年1月至2020年12月武汉市传染病医院32例免疫重建不全属脾肾亏虚型艾滋病患者作为研究对象,按随机数字表法将其分为治疗组和对照组,每组16例。治疗组16例采用高效抗逆转录病毒治疗(HAART)+健脾补肾免煎颗粒,对照组16例采用HAART+健脾补肾免煎颗粒模拟剂,两组均治疗48周。观察两组治疗前后患者肝肾功能、中医症状体征积分、卡洛夫斯基积分、免疫学指标。结果治疗后两组肝肾功能与治疗前比较,差异无统计学意义(P>0.05);治疗后两组中医症状体征积分较治疗前降低,且治疗组低于对照组(P<0.05);治疗后治疗组卡洛夫斯基积分较治疗前升高,且治疗组高于对照组(P<0.05);治疗后治疗组CD4^(+)CD45RA^(+)T细胞比例、CD4^(+)CD45RA^(+)T细胞/CD4^(+)CD45RO^(+)T细胞值较治疗前升高,且治疗组高于对照组(P<0.05);治疗后治疗组CD4^(+)CD45RO^(+)T细胞比例较治疗前降低,且治疗组低于对照组(P<0.05)。结论健脾补肾法治疗免疫功能重建不全脾肾亏虚型艾滋病患者具有良好的安全性,提高了患者的生活质量,改善了机体的免疫功能,表现出较好的协同作用。
Objective To observe the clinical effect of the method of invigorating spleen and tonifying kidney on acquired immunodeficiency syndrome patients.Methods A total of 32 acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney in Wuhan Infectious Disease Hospital from January 2017 to December 2020 were selected as research subjects,and they were divided into treatment group and control group according to random number table method,with 16 cases in each group.Sixteen patients in the treatment group were treated with highly active anti-retroviral therapy(HAART)+Jianpi Bushen Mianjian Granules,and sixteen patients in the control group were treated with HAART+Jianpi Bushen Mianjian Granule Simulation Agents.Both groups were treated for 48 weeks.The liver and kidney function,traditional Chinese medicine symptom and sign score,Karofsky score and immunological indexes of the two groups were observed before and after treatment.Results There was no significant difference in liver and kidney function between the two groups after treatment and before treatment(P>0.05).After treatment,the scores of traditional Chinese medicine symptoms and signs in the two groups were lower than those before treatment,and which in the treatment group were lower than those in the control group(P<0.05).After treatment,the Karofsky score in the treatment group was higher than that before treatment,and that in the treatment group was higher than that in the control group(P<0.05).After treatment,the proportion of CD4^(+)CD45RA^(+)T cells and the ratio value of CD4^(+)CD45RA^(+)T cells to CD4^(+)CD45RO^(+)T cells in the treatment group were higher than those before treatment,and those in the treatment group were higher than those in the control group(P<0.05).After treatment,the proportion of CD4^(+)CD45RO^(+)T cells in the treatment group was lower than that before treatment,and that in the treatment group were higher than the control group(P<0.05).Conclusion Invigorating spleen and tonifying kidney method has a good safety in the treatment of acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney,improving the quality of life of patients,improving the immune function of the body,showing a good synergistic effect.
作者
王映林
刘建忠
肖明中
倪维
陈瑶
余晓丽
贠凡
柯靖雯
WANG Yinglin;LIU Jianzhong;XIAO Mingzhong;NI Wei;CHEN Yao;YU Xiaoli;YUN Fan;KE Jingwen(Hubei Provincial Hospital of Traditional Chinese MedicineHubei Province Academy of Traditional Chinese Medicinethe Affiliated Hospital of Hubei University of Chinese Medicine,Hubei Province,Wuhan 430061,China;Wuhan Infectious Disease Hospital,Hubei Province,Wuhan 430022,China;School of Clinical Medicine,Hubei University of Chinese Medicine,Hubei Province,Wuhan 430065,China)
出处
《中国医药导报》
CAS
2022年第2期112-116,共5页
China Medical Herald
基金
国家自然科学基金资助项目(81774280)。
关键词
健脾补肾法
高效抗逆转录病毒治疗
艾滋病
免疫功能重建不全
Invigorating spleen and tonifying kidney method
Highly active anti-retroviral therapy
Acquired immunodeficiency syndrome
Incomplete immune reconstitution
作者简介
王映林(1978.8-),男,硕士,副主任医师,主要从事中医内科研究工作;通讯作者:刘建忠(1968.12-),男,博士,博士生导师,湖北省中医院副院长,主要从事中医内科研究工作。
