摘要
目的:分析妊娠期糖尿病(GDM)合并妊娠期高血压疾病(HDP)孕妇血清氧化应激指标变化及其与胰岛素抵抗关系。方法:选择2016年1月-2019年9月本院GDM合并HDP孕妇53例(合并组)、单纯GDM孕妇106例(单纯组)和血压血糖均正常孕妇106例(对照组),比较各组氧化应激指标丙二醛(MDA)、晚期蛋白氧化产物(AOPPs)、脂质过氧化氢(LHP)、总抗氧化能力(T-AOC)的差异,分析各指标与胰岛素抵抗的相关性。结果:血清MDA、AOPPs、LHP水平对照组<单纯组<合并组,T-AOC水平对照组>单纯组>合并组(P<0.05);血清MDA、AOPPs、T-AOC对GDM合并HDP有预测效能(P<0.05)。与对照组比较,合并组、单纯组OGTT时间-血糖曲线下面积、血清空腹血糖(FPG)、空腹胰岛素(FINS)水平、胰岛素抵抗指数(HOMA-IR)升高,胰岛β细胞功能指数(HOMA-β)降低,且合并组OGTT时间-血糖曲线下面积、血清FINS水平、HOMA-IR水平高于单纯组,HOMA-β低于单纯组(均P<0.05),FPG水平无差异(P>0.05);单纯GDM孕妇血清MDA、AOPPs水平与HOMA-IR呈正相关关系(P<0.05),T-AOC水平与HOMA-IR呈负相关关系(P<0.05),血清LHP水平与HOMA-IR无相关性(P>0.05);GDM合并HDP孕妇中,血清MDA、AOPPs、LHP水平与HOMA-IR呈正相关关系(P<0.05),T-AOC水平与HOMA-IR呈负相关关系(P<0.05)。结论:GDM合并HDP孕妇氧化应激损伤及胰岛素抵抗会更严重,且两者病理生理状态可能是相互促进关系。
Objective:To analyze the changes of oxidative stress indexes of pregnant women with gestational diabetes mellitus(GDM)combined with hypertensive disorders of pregnancy(HDP),and to study their relationship with the insulin resistance of the women.Methods:From January 2016 to September 2019,53 pregnant women with GDM and HDP were selected in group A,106 pregnant women with GDM alone were selected in group B,and 106 pregnant women with normal blood pressure value and blood glucose level were selected in group C.The differences of oxidative stress indexes,such as MDA,AOPPs,LHP,T AOC of the women were compared among the three groups,and which’s correlation with the insulin resistance of the women was analyzed.Results:The levels of serum MDA,AOPPs,and LHP of the women in group C were the lowest,then followed by those of the women in group B,and which of the women in group A were the highest.The T AOC level of the women in group C were the highest,then followed by those of the women in group B,and which of the women in group A were the lowest(P<0.05).The levels of serum MDA,AOPPs,and T AOC had predictive effects for GDM and HDP occurrences of the women(P<0.05).The OGTT time,the area under of the blood glucose curve,the serum FPG and FINS levels,the HOMA-IR value of the women in group A and group B were significantly higher than those of the women in group C,but the HOMA-βvalue of the women in group A and group B was significantly lower.The OGTT time,the area under of the blood glucose curve,the serum FINS level,and the HOMA-IR value of the women in group A were significantly higher than those of the women in group B,and the HOMA-βvalue of the women in group A was significantly lower(all P<0.05),but there was no significant difference in the FPG level of the women between group A and group B(P>0.05).In group B,the serum MDA and AOPPs levels of the women were positively correlated with their HOMA-IR value(P<0.05),the T-AOC level of the women was negatively correlated with their HOMA-IR value(P<0.05),but the serum LHP level of the women was no correlated with their HOMA-IR value(P>0.05).In group A,the serum MDA,AOPPs,and LHP levels of the women were positively correlated with their HOMA-IR value(P<0.05),while the T AOC level of the women was negatively correlated with their HOMA-IR value(P<0.05).Conclusion:The oxidative stress injury of the pregnant women with GDM and HDP is more serious,the pathophysiological states of GDM and HDP of the women are promoting each other.
作者
邵璐
SHAO Lu(Putuo District People's Hospital of Zhoushan, Zhejiang Province, 316100)
出处
《中国计划生育学杂志》
2021年第11期2412-2415,共4页
Chinese Journal of Family Planning
关键词
妊娠期糖尿病
妊娠期高血压疾病
氧化应激
胰岛素抵抗
Gestational diabetes mellitus
Hypertensive disorders of pregnancy
Oxidative stress
Insulin resistance
