摘要
目的探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)产妇应用地特胰岛素联合门冬胰岛素治疗的效果。方法选取2021年7月—2022年9月期间在平遥县人民医院进行分娩的GDM产妇66例为研究对象,按隐匿数字随机法分为单药组(33例,门冬胰岛素治疗),联合组(33例,门冬胰岛素+地特胰岛素治疗),观察记录两组血糖变化、胰岛素水平、母婴结局,进行比较分析。结果治疗前,两组患者血糖控制水平比较,差异无统计学意义(P>0.05);治疗后,联合组的空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2-hour postprandial blood glucose,2 hPG)、糖化血红蛋白(glycated hemoglobin,HbA1c)水平均低于单药组,差异有统计学意义(P<0.05);联合组的FPG达标、2 hFPG达标、FPG和2 hFPG均达标的时间均显著短于单药组,差异有统计学意义(P<0.05);联合组的自然分娩率为72.73%显著高于单药组的48.48%,差异有统计学意义(P<0.05);单药组的不良妊娠结局发生率(24.24%)高于联合组(9.09%),差异无统计学意义(P>0.05)。结论地特胰岛素联合门冬胰岛素治疗GDM患者,可以获得较为理想的血糖控制效果,能更快的使患者血糖达到理想的标准,自然分娩率更高。
Objective To explore the effect of insulin detemir combined with insulin aspart in the treatment of gestational diabetes mellitus(GDM).Methods 66 GDM women who gave birth in Pingyao County People's Hospital from July 2021 to September 2022 were selected as research objects.According to the concealed number random method,33 patients were divided into a single-drug group(treated with insulin aspart)and 33 patients were combination group(treated with insulin aspart+insulin detemir).Observed and recorded the data on blood sugar changes,insulin levels,and maternal and infant outcomes between the two groups for comparative analysis.Results Before treatment,there was no statistically significant difference in blood glucose control levels between the two groups(P>0.05).After treatment,the levels of fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG),and glycated hemoglobin(HbA1c)in the combination group were lower than those in the single-drug group,the difference was statistically significant(P<0.05).The time for FPG to reach the target,2 hPG to reach the target,and both FPG and 2 hPG to reach the target in the combination group were significantly shorter than those in the single-drug group,the difference were statistically significant(P<0.05).The natural delivery rate in the combination group was 72.73%,which was significantly higher than the 48.48%in the single-drug group,the difference was statistically significant(P<0.05).The incidence rate of adverse pregnancy outcomes in the single-drug group(24.24%)was higher than that in the combination group(9.09%),and the difference was statistically significant(P>0.05).Conclusion Insulin detemir combined with insulin aspart can achieve ideal blood sugar control effects in patients with GDM,and can bring patients'blood sugar to the ideal standard faster,and the natural delivery rate is higher.
作者
王霞
WANG Xia(Department of Obstetrics,Pingyao County People's Hospital,Jinzhong,Shanxi Province,031100 China)
出处
《糖尿病新世界》
2023年第18期113-116,共4页
Diabetes New World Magazine
关键词
妊娠期糖尿病
地特胰岛素
门冬胰岛素
母婴结局
Gestational diabetes
Insulin detemir
Insulin aspart
Maternal and fetal outcomes
作者简介
王霞(1979-),女,本科,副主任医师,研究方向为产科及相关疾病诊治。
