摘要
目的探讨联用银杏达莫与依达拉奉治疗缺血性脑卒中患者的临床效果。方法选取2019年3月至2020年6月朝阳市喀左县中心医院收治的82例缺血性脑卒中患者作为研究对象,按随机数字表法分为对照组与观察组,各41例。对照组在常规治疗基础上给予依达拉奉治疗,观察组在常规治疗基础上给予依达拉奉+银杏达莫治疗,比较两组治疗前后神经功能、日常生活活动能力、血清炎症介质、临床疗效及不良反应。结果治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)、白细胞介素-6(IL-6)比较,差异无统计学意义(P>0.05);治疗后,两组NIHSS评分、Hcy、CRP、IL-6水平低于治疗前,Barthel指数高于治疗前,且观察组NIHSS评分、Hcy、CRP、IL-6水平低于对照组,Barthel指数高于对照组,差异有统计学意义(P<0.05);观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论联用银杏达莫与依达拉奉治疗缺血性脑卒中可有效减轻患者神经功能损伤,恢复日常生活能力,降低血清炎症介质水平,是一种安全有效的治疗方式。
Objective To investigate the clinical effect of Ginkgo biloba and Edaravone on patients with ischemic stroke.Methods A total of 82 patients with ischemic stroke admitted to Central Hospital, Kazuo County, Chaoyang City from March 2019 to June 2020 were selected as the research objects and were divided into an observation group and a control group according to random number table method, with 41 cases in each group. The control group was treated with edaravone on the basis of routine treatment, and the observation group was treated with Edaravone +Ginkgo biloba on the basis of routine treatment. The nerve function, daily life activity, serum inflammatory factors, clinical efficacy and adverse reactions were compared before and after treatment. Results Before treatment, National Institutes of Health Stroke Scale(NIHSS), Barthel index, serum homocysteine(Hcy), C-reactive protein(CRP) and interleukin-6(IL-6) were compared between the 2 groups, the difference was not statistically significant(P>0.05);after treatment, the NIHSS scores and Hcy, CRP, IL-6 levels in both groups were lower than those before treatment. Barthel index was higher than that before treatment;the NIHSS score and Hcy, CRP, IL-6 level in the observation group were lower than those in the control group and Barthel index was higher than the control group. The difference was statistically significant(P<0.05). Conclusion Ginkgo biloba combined with Edaravone in the treatment of ischemic stroke can effectively reduce the damage of nerve function, restore the ability of daily life, reduce the level of serum inflammatory factors, which is a safe and effective treatment.
作者
纪德玉
JI De-Yu(Department one of Internal Medicine,Central Hospital,Kazuo County,Chaoyang City,Chaoyang 122399,China)
出处
《中国药物经济学》
2021年第12期105-107,124,共4页
China Journal of Pharmaceutical Economics
关键词
缺血性脑卒中
银杏达莫
依达拉奉
神经功能
炎症介质
不良反应
Ischemic stroke
Ginkgo biloba
Edaravone
Neurological function
Inflammatory factors
Adverse reactions
