摘要
目的:探讨依达拉奉联合银杏达莫对缺血性脑卒患者血清白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平的影响。方法:选取2014年6月—2015年6月江西省修水县中医院收治的缺血性脑卒中患者64例作为研究对象,以随机数字表法分为观察组和对照组各32例。对照组患者在常规治疗基础上给予银杏达莫注射液25 ml+5%葡萄糖注射液500 ml,静脉滴注,1日2次;观察组患者在对照组基础上给予依达拉奉30 mg+0.9%氯化钠注射液100 ml,静脉滴注,1日2次。观察2组患者的临床疗效,记录治疗前后2组患者欧洲卒中量表(the european stroke scale,ESS)和日常生活活动能力评分(activity of daily living scale,ADL),比较治疗前和治疗7、14 d后2组患者血清IL-6和TNF-α的水平。结果:观察组患者的总有效率显著高于对照组;治疗后,观察组患者的ESS评分显著低于对照组,ADL评分显著高于对照组;观察组患者治疗7、14 d后血清IL-6、TNF-α水平显著低于对照组,差异均有统计学意义(P<0.05)。结论:依达拉奉联合银杏达莫治疗缺血性脑卒中,疗效显著,能调节血清IL-6和TNF-α的水平,抑制炎症反应。
OBJECTIVE： To probe into the effects of edaravone combined with ginkgo-damole on IL-6 and TNF-αin patients with ischemic stroke. METHODS： 64 patients with ischemic stroke admitted into Jiangxi Provence Xiushui County Traditional Chinese Medicine Hospital from Jun. 2014 to Jun. 2015 were selected to be divided into observation group and control group via the random number table,with 32 cases in each. The control group were treated with ginkgo-damole injections 25 ml and 5% glucose injection 500 ml in intravenous drip,2 times / d,based on the conventional treatment. The observation group received edaravone 30 mg and 0. 9% Na Cl injection 100 ml in intravenous drip,2 times / d,based on the control group. The clinical efficacy of two groups were observed,the european stroke scale（ ESS） and active ability of daily life（ ADL） score before and after treatment were observed,and serum IL-6 and TNF-α level before and after treatment of 7 d and 14 d were compared. RESULTS： The total effective rate of observation group was higher than that of control group. After treatment,ESS score of observation group was significantly lower than that of control group,while ADL score was significantly higher than that of control group. The serum IL-6 and TNF-α level after treatment of 7 d and 14 d in observation group were significantly lower than those in control group,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of edaravone combined with ginkgo-damole on IL-6 and TNF- in patients with ischemic stroke is significant,which can regulate serum IL-6 and TNF-α level and inhibit inflammatory reactions.
出处
《中国医院用药评价与分析》
2016年第9期1169-1171,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
2015年江西省卫生厅科研计划课题(No.20155146)
作者简介
主管药师。研究方向：脑卒中的治疗、缺血性脑卒中的预防。E—mail：yanye1973@163.com.
