摘要
目的:探讨六君子汤加减对晚期非小细胞肺癌GP方案患者(肺脾气虚型)肿瘤指标、免疫功能的影响。方法:将肺脾气虚型晚期非小细胞肺癌并行GP方案化疗患者98例应用随机数字表法分为两组各49例。对照组采用GP方案,21天为1个化疗周期,观察组在对照组基础上予六君子汤加减治疗,2个化疗周期后比较疗效。结果:治疗后观察组血清细胞角蛋白19片段21-1(cell keratin 19 fragment 21-1,CYFRA21-1)、糖类抗原125(carbohydrate antigen 125,CA125)、神经元特异性烯醇化酶(Neuron-specific enolase,NSE)、血清血管内皮生长因子(Vascular endothelial growth factor,VEGF)、基质金属蛋白酶9(Matrix metalloproteinase-9,MMP-9)、血清碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)、前列腺素E2(prostaglandin E2,PGE2)等均低于对照组(P<0.05),治疗后观察组血清CD4^(+)/CD8^(+)、CD4^(+)细胞等T淋巴亚群水平高于对照组,差异有统计学意义(P<0.05);总有效率观察组为61.22%(30/49),对照组为40.82%(20/49),差异有统计学意义(P<0.05);观察组肝肾功能损伤、胃肠道反应、骨髓抑制等不良反应发生率低于对照组(P<0.05)。结论:GP方案联合六君子汤加减可抑制肺脾气虚型晚期非小细胞肺癌患者血管新生,改善免疫功能,预防肿瘤转移,降低化疗不良反应发生率。
Objective:To explore the influence of modified Liujunzi decoction on tumor indexes and immunity in advanced NSCLC patients of lung-spleen Qi deficiency pattern undergoing GP regimen.Methods:All 98 patients were allocated to two groups using random number table method,with 49 cases in each group.The control group adopted GP regimen,and 21 days were one course of chemotherapy,the observation group took modified Liujunzi decoction based on GP regimen,to compare clinical effects after two courses of chemotherapy.Results:After treating,the levels of CYFRA21-1,CA125,NSE,VEGF,MMP-9,bFGF and PGE_(2) of the observation group were lower than these of the control group,and the difference had statistical meaning(P<0.05);after treating,the levels of T lymphocyte subsets including CD4^(+)/CD8^(+),CD4^(+)cells of the observation group were higher than these of the control group,and the difference showed statistical meaning(P<0.05);total effective rate of the observation group was 61.22%(30/49),higher than 40.82%(20/49)of the control group,and there was a significant difference(P<0.05);the observation group was lower than the control group in the incidence of adverse reactions including liver and kidney function injury,gastrointestinal response and bone marrow suppression(P<0.05).Conclusion:GP regimen combined with modified Liujunzi decoction could inhibit the angiogenesis,improve the immunity,prevent tumor metastasis and reduce the incidence of chemotherapy-related adverse reaction.
作者
陈艳
孙连庆
胡粒山
CHEN Yan;SUN Lianqing;HU Lishan(The Ninth Division Hospital of Xinjiang Production and Construction Corps,Emin 834601,China;The First Affiliated Hospital of Xi'an Jiaotong University)
出处
《西部中医药》
2022年第1期119-123,共5页
Western Journal of Traditional Chinese Medicine
基金
新疆生产建设兵团第九师医院科技项目。
作者简介
陈艳(1980-),女,副主任医师。研究方向:肿瘤疾病的中医药防治。
