摘要
目的探讨中医药补肾化浊法联合硼替佐米联合地塞米松方案(BD方案)治疗多发性骨髓瘤的临床疗效。方法选取60例多发性骨髓瘤骨痛初治患者,随机分为对照组和治疗组,各30例。对照组给予BD方案化疗,治疗组在BD方案基础上联合补肾化浊法的中药(淫羊藿、补骨脂、党参、茯苓、白术、全蝎、蜈蚣、地龙、三七、甘草)治疗。比较两组患者治疗前后骨痛疼痛视觉模拟量表(VAS)评分、日常生活能力量表(ADL)评分、白细胞介素6(IL-6)水平,评价两组患者临床疗效。结果治疗后两组患者的骨痛VAS评分低于治疗前,且治疗组低于对照组(P<0.05)。治疗后,除两组的小便控制及对照组的洗澡、穿衣、用厕、平地行走外,两组其余ADL项目评分均高于治疗前(均P<0.05);除大小便控制外,治疗组其余ADL项目评分均高于对照组(均P<0.05)。治疗后两组患者的IL-6水平低于治疗前,且治疗组低于对照组(P<0.05)。治疗组患者临床疗效显著优于对照组(P<0.05)。结论补肾化浊法联合BD方案治疗多发性骨髓瘤可有效降低IL-6水平,有效缓解骨痛,在一定程度上改善患者生活质量。
Objective To explore the clinical efficacy of the tonifying kidney and resolving turbidity therapy combined with bortezomib plus dexamethasone regimen(BD regimen) for the treatment of multiple myeloma.Methods Sixty treatment-na6 ve patients with osteodynia due to multiple myeloma were selected and randomly divided into control group(n=30) and treatment group(n=30). The control group was given chemotherapy with BD regimen, and the treatment group was given the therapy with the combination of traditional Chinese drugs(epimedium herb, malaytea scurfpea fruit, tangshen, Indian bread, largehead atractylodes rhizome, scorpion, centipede, earthworm, sanqi, liquorice root) for tonifying kidney and resolving turbidity based on BD regimen. The Visual Analogue Scale(VAS) score for osteodynia, Activities of Daily Living Scale(ADL) score, and interleukin 6(IL-6) level were compared between the two groups before and after the treatment, and clinical efficacy was evaluated in the two groups.Results After the treatment, the VAS scores for osteodynia of the two groups were lower than those before the treatment, and the treatment group yielded lower scores than the control group(P<0.05). After the treatment, except the item of urination control in both groups as well as the items of taking a bath, wearing clothes, going to toilet, and walking on flat ground in the control group, the scores for the remaining ADL items in the two groups were higher than those before the treatment(all P<0.05);except the item of defecation and urination control, the treatment group exhibited higher scores for the remaining ADL items than the control group(all P<0.05). After the treatment, the level of IL-6 in the two groups was lower than that before the treatment, and the treatment group yielded a lower level over the control group(P<0.05). The treatment group was significantly superior to the control group in clinical efficacy(P<0.05).Conclusion The tonifying kidney and resolving turbidity therapy combined with BD regimen can effectively reduce the IL-6 level, effectively ameliorate osteodynia, and improve patients′ quality of life to a certain extent in the treatment of multiple myeloma.
作者
王佳
李晓红
李静
李美健
王辰辰
齐贺
WANG Jia;LI Xiao-hong;LI Jing;LI Mei-jian;WANG Chen-chen;QI He(Department of Hematology,the First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050000,China;The First Department of Orthopedics,Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Cangzhou 061000,China)
出处
《广西医学》
CAS
2021年第23期2824-2828,共5页
Guangxi Medical Journal
关键词
多发性骨髓瘤
骨痛
补肾化浊法
疼痛视觉模拟评分
白细胞介素6
日常生活活动能力
中西医结合治疗
Multiple myeloma
Osteodynia
Therapy of tonifying kidney and resolving turbidity
Visual Analogue Scale pain score
Interleukin 6
Activities of daily living
Integrated Chinese and Western medicine treatment
作者简介
王佳(1993-),女,硕士,住院医师,研究方向:血液内科,电子邮箱:wangjiaqihe520@163.com;通信作者:李晓红(1965-),女,博士,主任医师,教授,研究方向:血液内科学,电子邮箱:Hblxh2002@163.com。
