摘要
目的探讨硼替佐米联合常规化疗在多发性骨髓瘤中的治疗效果。方法选取2013年10月至2018年10月间山东省立第三医院收治的80例多发性骨髓瘤患者,根据治疗方式不同分为研究组和对照组,每组40例。对照组患者采用常规化疗(阿霉素+长春新碱+地塞米松),研究组患者在对照组基础上加用硼替佐米,比较两组患者治疗效果、不良反应和心理状态变化。结果研究组患者治疗有效率为95.0%,高于对照组的85.0%,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,研究组心理状态评分低于对照组,差异有统计学意义(P<0.05)。结论多发性骨髓瘤患者采用硼替佐米联合常规化疗治疗,效果确切,可在临床推广。
Objective To explore the therapeutic efficacy of bortezomib combined with conventional chemotherapy for multiple myeloma.Methods Eighty patients with multiple myeloma who admitted to Shandong Provincial Third Hospital from October 2013 to October 2018 were selected.They were divided into two a study group and a control group according to different therapies they received with 40 patients in each group.The study group was treated with bortezomib combined with doxorubicin plus vincristine and dexamethasone and the control group was only given conventional chemotherapy with doxorubicin plus vincristine and dexamethasone.Treatment efficacy,adverse reactions,and changes in psychological state were compared between the two groups.Results The efficacy rate was 95.0%in the study group which was higher than 85.0%of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After the treatment,the scores of psychological state were lower in the study group than in the control group(all P<0.05).Conclusion The efficacy of bortezomib combined with conventional chemotherapy is obvious in patients with multiple myeloma and it can be widely promoted and applied in clinical practice.
作者
马悦
邢姚姚
康贵云
胡浩然
MA Yue;XING Yao-yao;KANG Gui-yun;HU Hao-ran(Department of Oncohaematology,Shandong Provincial Third Hospital,Jinan 251200,China;Department of Geriatrics,Shandong Provincial Third Hospital,Jinan 251200,China;Department of Pediatrics,Children's Hospital of Jinan,Jinan 250000,China;Department of Infirmary,Shandong Provincial Third Hospital,Jinan 251200,China)
出处
《中国肿瘤临床与康复》
2020年第3期285-287,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
作者简介
马悦,男,医师,主要从事恶性血液病诊断及治疗专业;通信作者:胡浩然,Email:15169102782@163.com
