摘要
神经可以支配人体组织,对运动、感觉和发育等功能起到重要调控作用,神经调节在肿瘤发生、发展过程中的作用越来越被重视,脑内神经祖细胞可以直接随血循环迁徙到肿瘤部位,促进肿瘤生长。本文综述了脑内神经元影响颅外肿瘤的各种途径,脑内神经元可以通过肿瘤内的神经纤维直接促进肿瘤生长或促进瘤内血管新生,并且脑内神经元亦可通过内分泌和免疫系统间接影响颅外肿瘤生长进程。基于神经对颅外肿瘤生长的重要调控作用,近年来,去神经支配、β受体阻滞剂及环境和行为治疗等方法在抑制肿瘤生长的基础研究中取得了良好的效果。通过手术或化学方法去除神经负面效应,已被证实可以延缓肿瘤的进展。多项研究表明,β受体阻滞剂可以显著延长肺癌、前列腺癌等癌症患者的生存期。运动和积极心态使得下丘脑分泌的脑源性营养因子对于抑制肿瘤细胞的增殖和扩展起到重要作用。通过对近年来神经在肿瘤发生、发展中的作用及针对肿瘤的相关神经治疗方法进行综述,为肿瘤的发生、发展机制以及诊断预后提供了新的视角。
Nerves can innervate human tissues and play an important role in many functions such as movement,sensation,development,etc.Growing attention has been paid to the role of neuromodulation in tumorigenesis and development,as indicated by the latest research showing direct transfer of intracerebral neural progenitors to the tumor site with the blood circulation to promote tumor growth.This article reviewed the various ways in which neurons in the brain affect extracranial tumors.Intracerebral neurons can either promote tumor growth directly or by generating angiogenesis.Besides,it has also been suggested that neurons in the brain can accelerate the growth of extracranial tumors through the endocrine and immune system.Based on the vital regulatory effect of nerves,methods such as denervation,application of β blockers,and environmental and behavioral treatments have achieved progress in basic experiments in controlling tumor growth.Removal of negative nerve effects through surgical or chemical ways has been proven to delay tumor progression.Numerous studies have also shown thatβblockers could significantly prolong the survival time of cancer patients such as lung cancer and prostate cancer.Moreover,exercise and a positive attitude increase hypothalamic secretion of brain-derived nutritional factors,which play an inevitable role in inhibiting the proliferation and expansion of tumor cells.In this article,we provided a new perspective on the mechanism as well as the role of nerves in tumorigenesis and development in recent years,and meanwhile,giving insight into the related neurotherapy for tumors.
作者
王钰
杜岳姗(综述)
范兴文(审校)
WANG Yu;DU Yueshan;FAN Xingwen(Department of Integrative Medicine and Neurobiology,School of Basic Medical Sciences,Academy of Integrative Medicine,Institute of Acupuncture Research,Fudan University,Shanghai 200032,China;Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China)
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2021年第12期1215-1219,共5页
China Oncology
基金
国家自然科学基金(81903252
81872551)。
关键词
神经
肿瘤
治疗
Neurons
Tumor
Treatment
作者简介
通信作者:范兴文,E-mail:wenxingfan@126.com。
