摘要
目的分析多学科治疗模式对脑转移瘤患者的预后影响因素。方法回顾性分析2015—2018年在武警部队肿瘤放射诊疗中心曾行分次立体定向放疗的脑转移瘤患者共109例,其中行多学科治疗33例,同期未行多学科治疗76例。比较两组的肿瘤局部控制率、中位生存期,并分析相关影响因素。结果患者中位随访时间为12.7个月(3.6~48.0个月),全组患者中位总生存期为13.9个月。多学科治疗组与非多学科治疗组的肿瘤局部控制率分别为90.9%与85.5%(P=0.704),中位总生存期分别为15.3个月与11.8个月(P=0.031)。多因素分析显示影响患者预后因素为高GPA评分(P=0.032)、无颅外肿瘤(P=0.043)、有驱动基因(P<0.001)及多学科治疗(P=0.002)。结论多学科治疗模式可能有效改善患者预后,延长脑转移瘤患者的生存期。
Objective:To analyze the influence of multidisciplinary treatment(MDT)on the survival and prognosis of patients with brain metastases and analyze the relevant factors.Methods:From January 2015 to December 2018,a total of 109 patients with brain metastases who had undergone stereotactic radiotherapy were analyzed retrospectively,including 33 patients who had undergone MDT,and 76 patients who had not undergone MDT at the same time.The clinical characteristics of the two groups were analyzed,and the local control rate and median survival time of the two groups were compared,and the relevant influencing factors were analyzed.Results:The median follow-up time of the patients was 12.7 m.The median survival time of all patients was 13.9 months.The local control rate of tumor in the MDT group and the non-MDT group was 90.9%and 85.5%,respectively(P=0.704),with the median survival time 15.3 months in the MDT group and 11.8 months in the non-MDT group(P=0.031).The good prognostic factors were high GPA score(P=0.032),no extracranial tumor(P=0.043),positive driving gene(P<0.001)and MDT(P=0.002).Conclusion:The MDT mode may effectively improve the prognosis and prolong the survival time of patients with brain metastasis.
作者
王猛
李勇
梁康宁
邵显军
吴俊兰
岳倩
潘绵顺
Wang Meng;Li Yong;Liang Kangning;Shao Xianjun;Wu Junlan;Yue Qian;Pan Mianshun(Center of Radiation Oncology,Shanghai Wujing Hospital,Shanghai 201103,China)
出处
《中华转移性肿瘤杂志》
2020年第1期20-24,共5页
Chinese Journal of Metastatic Cancer
基金
上海市长宁区肿瘤放射诊疗中心特色专科建设项目(20193006)
关键词
脑转移瘤
多学科治疗
预后因素分析
Brain metastases
Multidisciplinary treatment
Prognosis factor analysis
作者简介
通信作者:潘绵顺,Email:panmianshun@126.com
