摘要
目的分析1990—2019年中国喉癌疾病负担的变化趋势。方法基于全球疾病负担研究数据库对比分析1990—2019年我国和全球喉癌的发病率、死亡率、伤残调整寿命年(disability adjusted life years,DALYs)、过早死亡损失寿命年、伤残损失寿命年及年估计变化百分比(estimated annual percentage change,EAPC),并进一步分析我国不同年龄、性别及喉癌归因危险因素的疾病负担情况。结果2019年中国喉癌发病例数、死亡例数和DALYs分别为4.54万、2.03万和49.79万人年,比1990年分别增加了221.98%、76.20%和56.72%。1990—2019年中国喉癌标化发病率呈上升趋势(EAPC=1.32),而标化死亡率(EAPC=-0.96)和标化DALYs率(EAPC=-1.21)均呈下降趋势。我国喉癌的发病、死亡和疾病负担在50~69岁年龄组开始明显上升,≥70岁达到最高,且男性显著高于女性。与1990年相比,2019年我国可归因于吸烟、饮酒和石棉暴露的喉癌死亡比例和DALYs比例均有所增加;可归因于硫酸暴露的喉癌死亡比例和DALYs比例均有所下降。结论1990—2019年我国喉癌的标化发病率呈上升趋势,而标化死亡率和标化DALYs率均呈下降趋势,疾病负担在男性中明显高于女性,中老年人群的疾病负担仍较为沉重,提示仍需进一步加强喉癌的防治工作。
Objective To analyze the trend of disease burden of larynx cancer in China from 1990 to 2019.Method Data were obtained from the results of global burden of disease.The incidence,mortality,disability adjusted life years(DALYs),years of life lost,years lived with disability,and the estimated annual percentage change(EAPC)were used to describe the changes of disease burden of larynx cancer in China and the world between 1990 and 2019.Further analysis of the disease burden of larynx cancer in China by age,sex,and attributable risk factor.Result In 2019,the number of incident case,deaths and DALYs of larynx cancer in China was 45400 cases,20300 cases and 497.9 thousand person-years,respectively,an increase of 221.98%,76.20%and 56.72%from 1990.The agestandardized incidence rate of larynx cancer in China showed an upward trend(EAPC=1.32),while the age-standardized mortality rate(EAPC=-0.96)and the age-standardized DALYs rate(EAPC=-1.21)showed a downward trend during the past three decades.The disease burden of larynx cancer in China had increased significantly in the 50 to 69 years old age group,reaching the highest at≥70 years old,and was significantly higher in men than in women.The proportion of larynx cancer deaths and DALYs attributable to smoking,alcohol use,and occupational exposure to asbestos increased in 2019.The proportion of larynx cancer deaths and DALYs attributable to occupational exposure to sulfuric acid decreased.Conclusion From 1990 to 2019,the age-standardized incidence rate of larynx cancer in China showed an upward trend,while the age-standardized mortality rate and age-standardized DALYs rate showed a downward trend.The disease burden of larynx cancer is significantly higher in men than in women,and the burden of middle-aged and elderly people is heavy.It is necessary to strengthen the prevention and treatment of larynx cancer.
作者
龚恒
吴俐萍
吴倩
李艳琴
訾豪
王娜
曾宪涛
倪小兵
Gong Heng;Wu Liping;Wu Qian;Li Yanqin;Zi Hao;Wang Na;Zeng Xiantao;Ni Xiaobing(Department of Ear,Nose and Throat,Taihe Hospital,Hubei University of Medicine,Hubei,Shiyan 442000,China;Department of Stomatology,Taihe Hospital,Hubei University of Medicine,Hubei,Shiyan 442000,China;Center for Evidence-Based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)
出处
《中国医学前沿杂志（电子版）》
2021年第12期53-59,共7页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
国家发改委、国家卫健委疑难病症诊治能力提升工程项目(ZLYNXM202009)。
关键词
喉癌
发病率
死亡率
疾病负担
伤残调整寿命年
Larynx cancer
Incidence
Mortality
Burden of disease
Disability adjusted life years
作者简介
通信作者:倪小兵,E-mail:xb2002kq@163.com。
