摘要
大部分肥胖患者体内出现瘦素抵抗,表现为血清瘦素水平异常升高,但机体对瘦素不敏感或无反应,使瘦素抑制食欲、增加能量消耗和降低血糖等功能不能有效发挥.减轻瘦素抵抗被认为是治疗肥胖及肥胖相关疾病的有效途径.运动减轻肥胖、改善糖脂代谢和增强胰岛素敏感性的作用与运动降低瘦素水平、改善瘦素抵抗密切相关.本文在概述瘦素实现生理功能的机制、肥胖症的中枢及外周瘦素抵抗的基础上,主要综述近年来运动减轻肥胖症瘦素抵抗机制的研究进展,包括减轻高瘦素血症、改善中枢和外周瘦素抵抗,以期为运动防治肥胖机制的研究提供新视角.
Most of obese subjects show leptin resistance,characterized by abnormal increase of serum leptin but diminished effects of leptin on inhibiting appetite,enhancing energy expenditure and decreasing blood glucose.Reducing leptin resistance is considered as an effective strategy to treat obesity and obesity related diseases.Exercise decreases obesity,improves glycolipid metabolism and increases insulin sensitivity,which are closely related to exercise-induced decrease of serum leptin and alleviation of leptin resistance.This review mainly summarized the mechanisms of exercise-induced improvements of leptin resistance in obesity,including lowering hyperleptinaemia and decreasing central and peripheral leptin resistance.Alleviation of hyperleptinaemia in obesity by exercise attributes to decreased fat mass and improved inflammation.For the decrease of central leptin resistance in obesity,exercise modulates neurons activities(stimulating SF-1,POMC neurons and inhibiting AgRP neurons)and other molecules related to energy metabolic homeostasis and food intake(elevating hypothalamic IL-6),and regulates expressions of proteins involved in leptin signaling of hypothalamus(stimulating STAT3,and inhibiting PTP1 B and SOCS3);while exercise-induced decrease of peripheral leptin resistance comes from improvements of body composition(decreased fat mass,increased brown adipose tissue and reduced inflammation)and regulation of protein expressions involved in leptin signaling in muscle and liver(inhibiting SOCS3 and PTP1 B).This review could provide a new insight into the mechanism of exercisemediated prevention and treatment of obesity.
作者
彭瑾
杨亚军
王晓慧
PENG Jin;YANG Ya-Jun;WANG Xiao-Hui(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China;Institute of Physical Education,Xingyi Normal University for Nationalities,Xingyi 562400,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2021年第9期1023-1030,共8页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(31872801)
贵州省教育厅青年科技人才成长项目(黔教合KY字[2018]416)资助。
关键词
运动
肥胖
瘦素
中枢瘦素抵抗
外周瘦素抵抗
exercise
obesity
leptin
central leptin resistance
peripheral leptin resistance
作者简介
通讯联系人:王晓慧.Tel:021-65507509,E-mail:wangpan96@126.com。
