摘要
目的:观察汉防己甲素片联合肺泡灌洗术治疗尘肺合并慢性阻塞性肺疾病(简称慢阻肺)患者的临床效果。方法:回顾性分析2019年8月至2020年12月300例尘肺合并慢阻肺患者的临床资料,按不同治疗方案分为对照组125例和观察组175例。对照组采用肺泡灌洗术治疗,观察组在对照组基础上联合汉防己甲素片治疗,比较两组治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))及最大自主通气量(MVV)]水平、血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]水平、炎性因子[白细胞介素(IL)-6、IL-8和肿瘤坏死因子-α(TNF-α)]水平和不良反应发生率。结果:治疗后,观察组FVC、FEV_(1)、MVV和PaO_(2)均高于对照组,PaCO_(2)、IL-6、IL-8和TNF-α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:汉防己甲素片联合肺泡灌洗术治疗尘肺合并慢阻肺患者可提高肺功能指标水平,改善血气指标水平,降低炎性因子水平,效果优于单纯肺泡灌洗术治疗。
Objective:To observe Effects of Tetrandrine tablets combined with alveolar lavage in treatment of pneumoconiosis patients complicated with chronic obstructive pulmonary(COPD).Methods:The clinical data of 300 patients with pneumoconiosis complicated with COPD from August 2019 to December 2020 were retrospectively analyzed.According to different treatment plans,they were divided into control group(125 cases)and observation group(175 cases).The control group was treated with alveolar lavage,while the observation group was treated with Tetrandrine tablets on the basis of that of the control group.The pulmonary function index levels[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))and maximal voluntary ventilation(MVV)],the blood gas index levels[arterial partial pressure of oxygen(PaO_(2)),arterial carbon dioxide partial pressure(PaCO_(2))],the inflammatory factor levels[interleukin(IL)-6,IL-8 and tumor necrosis factor-α(TNF-α)]and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of FVC,FEV_(1),MVV and PaO_(2) in the observation group were higher than those in the control group;the levels of PaCO_(2),IL-6,IL-8 and TNF-αlevels were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tetrandrine tablets combined with alveolar lavage in the treatment of the patients with pneumoconiosis complicated with COPD can improve the levels of pulmonary function indicators,improve the levels of blood gas indicators,and reduce the levels of inflammatory factors.Moreover,it is superior to single alveolar lavage treatment.
作者
孙雪梅
SUN Xuemei(The Third People’s Hospital of Beipiao City,Beipiao 122100 Liaoning,China)
出处
《中国民康医学》
2021年第21期7-9,共3页
Medical Journal of Chinese People’s Health
关键词
汉防己甲素片
肺泡灌洗术
尘肺
慢阻肺
血气指标
肺功能
炎性因子
Tetrandrine tablets
Alveolar lavage
Pneumoconiosis
COPD
Blood gas index
Pulmonary function
Inflammatory factor
作者简介
孙雪梅(1967.12-),女,汉族,辽宁北票人,本科,副主任药师,研究方向为临床西药学。
