摘要
汉防己,又称粉防己,能够祛风止痛,利水消肿,是一种治疗风湿痹痛的传统中药。生物碱在粉防己中具有重要的药效物质基础,汉防己甲素属于其中的双苄基异喹啉类生物碱成分,生物活性多样,可以从多个方面实现抗肿瘤的作用,临床上也验证了其对多种炎症因子的抑制作用,对肝纤维化、肾纤维化等多种纤维化类疾病也有较好的防治作用,并且在与多种药物联合用药时,能够体现出良好的协同作用。近年来,经过国内外学者不断深入的研究,还发现汉防己甲素对神经系统以及缺血再灌注损伤也有一定的保护作用,同时,作为一种钙离子拮抗剂,汉防己甲素能够有效阻断细胞内外钙离子的沉积。综上所述,汉防己甲素在临床上的应用前景十分广泛,该文通过对上述及其他已经报道的汉防己甲素的药理作用进行了归纳,总结其各个药理作用实现的可能机制,综述其目前的研究进展,希望能够较为全面地揭示出汉防己甲素可能的应用方向,为其能够更好地在临床上应用提供启示和思路。
Han stephania,also known as Stephania tetrandra,expelling wind,relieve pain and inducing diuresis for removing edema,is a traditional Chinese medicine for treating rheumatic arthralgia.Alkaloids have an important pharmacodynamic basis in S.tetrandra,and tetrandrine is one kind content of bisbenzylisoquinoline alkaloids,which has many biological activities.These activities include anti-tumor in many ways,clinically inhibiting multiple inflammatory factors,preventing and treating liver fibrosis and renal fibrosis and many other kinds of fibrotic diseases,and in addition,tetrandrine could work synergistically with other drugs.In recent years,through in-depth research by scholars at home and abroad,it has been found that tetrandrine has a protective effect on the nervous system and ischemia-reperfusion injury.At the same time,as a calcium ion antagonist,tetrandrine could effectively block the deposition of calcium ions inside and outside the cell.In summary,the application prospect of tetrandrine in clinical practice is very extensive.In this paper,the pharmacological effects of tetrandrine and the possible mechanisms for these effects are summarized,and review its current research progress.It is hoped that the possible application direction of tetrandrine can be revealed more comprehensively,and provide better enlightenment and ideas for clinical application.
作者
席苑
张海静
叶祖光
张广平
XI Yuan(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第1期20-28,共9页
China Journal of Chinese Materia Medica
基金
国家“重大新药创制”科技重大专项(2015ZX09501004-003-002)
中央级公益性科研院所基本科研业务费专项(ZXKT18017).
关键词
汉防己甲素
药理作用
研究进展
tetrandrine
pharmacological action
research development
作者简介
席苑,E-mail:xy2725602289@126.com;通信作者:张广平,副研究员,E-mail:iamzgp@163.com;通信作者:叶祖光,研究员,博士生导师,E-mail:zgye@icmm.ac.cn
