安宫牛黄丸联合软通道穿刺引流术对高血压性脑出血患者氧化应激和内皮功能的影响被引量：15

Effects of Angong Niuhuang Pills Combined with Soft Channel Puncture Drainage on Oxidative Stress and Endothelial Function in Treatment of Patients with Hypertensive Cerebral Hemorrhage

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摘要目的探讨安宫牛黄丸联合软通道穿刺引流术对高血压性脑出血患者氧化应激和内皮功能的影响。方法选取2018年4月—2020年10月收治的高血压性脑出血84例,根据治疗方法不同将其分为观察组和对照组两组各42例。观察组采用安宫牛黄丸联合软通道穿刺引流术治疗,对照组采用软通道穿刺引流术治疗。观察比较两组治疗前后氧化应激、内皮功能、神经功能和临床相关指标,以及治疗期间不良反应。结果治疗前,两组氧化应激、内皮功能、神经功能和临床相关指标比较差异无统计学意义(P>0.05)。治疗后,观察组血清超氧化物歧化酶、谷胱甘肽过氧化物酶、血管内皮生长因子和神经生长因子水平高于对照组,血清丙二醛和内皮素-1水平低于对照组;美国国立卫生研究院卒中量表评分、颅内血肿体积、颅内压和中医症候评分小于或低于对照组,格拉斯哥昏迷量表和Barthel指数评分高于对照组(P<0.01)。治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论安宫牛黄丸联合软通道穿刺引流术能改善高血压性脑出血患者氧化应激反应和内皮功能,促进神经功能恢复,且安全性较好。 Objective To explore effects of Angong Niuhuang Pills combined with soft channel puncture drainage on oxidative stress and endothelial function in treatment of patients with hypertensive intracerebral hemorrhage(HIH).Methods A total of 84 patients with HIH admitted between April 2018 and October 2020 were enrolled and divided into observation group(n=42)and control group(n=42)according to different therapeutic methods.Observation group was treated with Angong Niuhuang Pills combined with soft channel puncture drainage,while control group was treated with soft channel puncture drainage.The oxidative stress,endothelial function,neurological function and clinical related indexes before and after treatment as well as incidence rate of adverse reactions during the treatment were observed and compared in two groups.Results There were no statistically significant differences in oxidative stress,endothelial function,neurological function and clinical related indexes before treatment between two groups(P>0.05).After treatment,in observation group,serum levels of superoxide dismutase,glutathione peroxidase,vascular endothelial growth factor and nerve growth factor were significantly higher,while serum levels of malondialdehyde and endothelin-1 were significantly lower than those in control group;scores of USA National Institutes of Health Stroke Scale(NIHSS),intracranial hematoma volume,intracranial pressure and TCM syndrome scores were significantly lower,while scores of Glasgow Coma Scale and Barthel Index were significantly higher than those in control group(P<0.01).There was no significant difference in incidence rate of adverse reactions during the treatment between two groups(P>0.05).Conclusion Angong Niuhuang Pills combined with soft channel puncture drainage may improve oxidative stress reaction and endothelial function and promote the rehabilitation of nerve function with good safety in treatment of patients with HIH.

作者彭国宏姚晨张恒柱 PENG Guo-hong;YAO Chen;ZHANG Heng-zhu(Department of Neurosurgery,Jiangyan Hospital of Traditional Chinese Medicine,Taizhou,Jiangsu 225500,China;Department of Neurosurgery,Subei People's Hospital,Yangzhou,Jiangsu 225001,China)

机构地区泰州市姜堰中医院神经外科苏北人民医院神经外科

出处《临床误诊误治》 CAS 2021年第11期35-39,共5页 Clinical Misdiagnosis & Mistherapy

基金江苏省卫生健康委2018年度科研项目(H2018064)。

关键词颅内出血高血压性安宫牛黄丸软通道穿刺引流术超氧化物歧化酶丙二醛血管内皮生长因子神经生长因子神经功能 Intracranial hemorrhage,hypertensive Angong niuhuang pill Soft channel hematoma puncture drainage Superoxide dismutase Malondialdehyde Vascular endothelial growth factor Nerve growth factor Nerve function

分类号 R743.34 [医药卫生—神经病学与精神病学]

作者简介彭国宏,本科,副主任医师。主要从事神经外科急危重症诊治方向研究。