摘要
天然牛黄价格昂贵,且资源匮乏,难以满足临床需求。目前市售牛黄包括天然牛黄、体外培育牛黄、人工牛黄和培植牛黄4种。该研究基于Web of Science、PubMed和CNKI数据库检索牛黄类药材及其中成药相关文献,利用CiteSpace软件、citexs AI和CNKI计量可视化开展文献计量分析,并绘制可视化知识图谱,进而全面、科学阐明牛黄类药材及其中成药的研究进程、研究方向和研究热点等。研究结果显示,牛黄类药材及其中成药的研究经历了缓慢发展和3次典型增长阶段,其与天然牛黄代用品的开发研究及国家对中医药产业发展政策的出台相一致,目前处于稳步上升阶段。近年来我国对牛黄类药材及其中成药的研究较为活跃,研究方向涉及牛黄类药材及其中成药的质量控制、安宫牛黄丸等中成药的药理药效、牛黄类药材的质量对比等,但是对于牛黄类药材的药理药效及其机制研究偏少。研究表明,牛黄类药材及其中成药的研究初步形成了多元化研究视角,我国在该领域的地位逐渐突出,但尚需通过多维度、深层次的研究揭示牛黄类药材的化学成分构成、药理药效及作用机制。
With scarce resources,natural Bovis Calculus is expensive and hard to meet clinical demand.At the moment,four kinds of Bovis Calculus are available on the market:the natural product,in vitro cultured product,synthesized product,and the product formed in cow after manual intervention.In this study,papers on the four kinds of Bovis Calculus products and relevant Chinese patent medicines were searched from Web of Science,PubMed,and China National Knowledge Infrastructure(CNKI).CiteSpace,citexs AI,and CNKI were employed for bibliometric analysis and knowledge map analysis.On this basis,the status,trend,and focuses of research on Bovis Calculus and relevant Chinese patent medicines were summarized.The results suggested overall slow development in the research on Bovis Calculus and relevant Chinese patent medicines with three typical growth stages.It is consistent with the development of Bovis Calculus substitutes and the national policy for the development of traditional Chinese medicine.At the moment,the research on Bovis Calculus and relevant Chinese patent medicines has been on the rise.In recent years,there has been an explosion of research on them,particularly the quality control of Bovis Calculus and the Chinese patent medicines,the pharmacological efficacy of Chinese patent medicines,such as Angong Niuhuang Pills,and the comparison of the quality of various Bovis Calculus products.However,there is a paucity of research on the pharmacological efficacy and the mechanism of Bovis Calculus.This medicinal and the relevant Chinese patent medicines have been studied from diverse perspectives and China becomes outstanding in this research field.However,it is still necessary to reveal the chemical composition,pharmacological efficacy,and mechanism through multi-dimensional deep research.
作者
王璟
卢有媛
谢明霞
贺凯
尚博扬
王涛
王汉卿
WANG Jing;LU You-yuan;XIE Ming-xia;HE Kai;SHANG Bo-yang;WANG Tao;WANG Han-qing(Ningxia Engineering and Technology Research Center for Modernization of Regional Characteristic Traditional Chinese Medicine,Ningxia Regional Characteristic Traditional Chinese Medicine Collaborative Innovation Center Co-constructed by the Province and Ministry,College of Pharmacy,Ningxia Medical University,Yinchuan 750004,China;School of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410007,China;Ningxia Institute for Drug Control,Yinchuan 750004,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2023年第8期2092-2102,共11页
China Journal of Chinese Materia Medica
基金
中央本级重大增减支项目(2060302)
宁夏回族自治区重点研发项目(2022BEG03149)。
关键词
牛黄
培植牛黄
体外培育牛黄
人工牛黄
中成药
研究现状
Bovis Calculus
Bovis Calculus formed in cow after manual intervention
in vitro-cultured Bovis Calculus
synthesized Bovis Calculus
Chinese patent medicines
research status
作者简介
通信作者:王汉卿,教授,硕士生导师,主要从事中药资源开发利用研究,E-mail:wwwhhq@163.com;通信作者:卢有媛,副研究员,硕士生导师,主要从事中药质量特征研究,E-mail:luyylhy@163.com;王璟,硕士研究生,E-mail:m15735213692@163.com。
