摘要
海藻酸钠(SA)是一种天然高分子聚合物,而纳米银(Ag)具有良好的抗菌性,因此利用二者制备的水凝胶敷料在生物医学领域具有广阔的应用前景。本文首先将Ag纳米颗粒负载于氧化石墨烯(GO)片表面得到Ag/石墨烯复合物(Ag-GO),然后再将其添加到SA中,通过溶胶-凝胶法获得负载Ag-GO的双层海藻酸钠水凝胶薄膜(Ag-GO/SA)。利用FTIR、XRD和SEM等技术对Ag-GO/SA的组成结构和微观形貌进行了表征,并评价了其溶胀性、抗菌性、力学、体外细胞毒性和体内伤口愈合能力等性能。结果表明Ag-GO/SA具有良好的溶胀性、力学强度和抗菌性等性能,与医用纱布相比,Ag-GO/SA可促进SD大鼠的伤口愈合,伤口愈合率高达98%,作为新型伤口敷料具有很大的应用潜力。
Sodium alginate(SA)is a natural polymer material that has been widely studied and used in the biomedical field.Nano-silver(Ag)has been proven to present good antibacterial properties,but its application is limited due to its easy agglomeration.In this paper,a series of Ag-graphene composites(Ag-GO)were prepared and characterized by loading Ag nanoparticles on the surface of graphene oxide(GO)sheets.Ag-GO was then added into SA,and a double-layered SA hydrogel film(Ag-GO/SA)carrying Ag-GO was prepared by sol-gel process.FTIR,XRD and SEM characterizations were used to determine the chemical structure and micromorphology of Ag-GO/SA.In addition,swelling ability,mechanical and antibacterial properties,as well as in-vitro cytotoxicity and in-vivo wound healing ability of Ag-GO/SA samples were also evaluated.The results show that the prepared Ag-GO/SA has good swelling property,sufficient mechanical strength,excellent wound healing and antibacterial properties.Specially,the optimum hydrogel of Ag-GO/SA can promote wound healing in SD rats,with a wound healing rate of up to 98%,presenting great application potential as a new type of wound dressing.
作者
王婷婷
王金清
岳铭强
范增杰
杨生荣
WANG Tingting;WANG Jinqing;YUE Mingqiang;FAN Zengjie;YANG Shengrong(State Key Laboratory of Solid Lubrication,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China;Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China;School of Chemical Engineering,Northwest Minzu University,Lanzhou 730000,China;School of Stomatology,Lanzhou University,Lanzhou 730000,China)
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2021年第9期3008-3017,共10页
Acta Materiae Compositae Sinica
基金
国家自然科学基金(51975562)。
关键词
纳米银/石墨烯复合物
海藻酸钠
双层水凝胶
抗菌性
伤口愈合
nano-silver/graphene composite
sodium alginate
double-layer hydrogel
antibacterial property
wound healing
作者简介
通信作者:杨生荣,硕士,研究员,博士生导师,研究方向为聚合物复合材料,E-mail:sryang@licp.cas.cn。
