摘要
目的:探讨功能性便秘(FC)患者肠道菌群与病情的关系。方法:选取2018年1月—2020年8月入院的100例FC患者,依据病情分为轻度组(n=18)、中度组(n=52)和重度组(n=30),同期选取健康人员100例为健康组,检测所有肠道菌群并记录每周自发完全排便(SCBM)次数,分析FC患者肠道菌群与病情的关系。结果:FC患者组双歧杆菌、乳酸菌数量和SCBM次数低于健康组,FC患者组肠球菌、肠杆菌数量高于健康组,差异有统计学意义(P<0.05);在双歧杆菌、乳酸菌数量和SCBM次数中,重度组低于中度组,中度组低于轻度组,差异有统计学意义(P<0.05);在肠球菌、肠杆菌数量中,重度组高于中度组,中度组高于轻度组,差异有统计学意义(P<0.05);Pearson相关性分析显示,双歧杆菌、乳酸菌数量与SCBM次数呈负相关,肠球菌、肠杆菌数量与SCBM次数呈正相关(P<0.05)。结论:FC患者存在肠道菌群失调,其肠道菌群失调与病情有关。
Objective: To discuss the relationship between the intestinal flora and disease condition in patients with functional constipation(FC). Methods: The 100 patients with FC in our hospital from January 2018 to August 2020 were selected, and they were divided into the mild group(n=18), moderate group(n=52) and severe group(n=30) according to disease condition. At the same time, the 100 healthy people were selected, the intestinal flora of all subjects was detected, and the times of spontaneous complete defecation bowel movements(SCBM) was recorded, and the relationship between the intestinal flora and disease condition of patients with FC was analyzed. Results: The number of bifidobacteria and Lactobacillus and the times of SCBM in the patients with FC were lower than those in the healthy people, the number of Enterococcus and Enterobacteriaceae in the patients with FC was higher than those in the healthy people, the difference was statistically significant(P<0.05). In the number of bifidobacteria and Lactobacillus and the times of SCBM, the severe group were lower than the moderate group, the moderate group were lower than the mild group, the difference was statistically significant(P<0.05). In the number of Enterococcus, Enterobacteriaceae, the severe group was higher than the moderate group, the moderate group was higher than the mild group, the difference was statistically significant(P<0.05). The Pearson correlation analysis showed that, the number of bifidobacteria and Lactobacillus was negatively correlated with the times of SCBM, the number of Enterococcus and enterobacteria was positively correlated with the times of SCBM(P<0.05). Conclusion: The patients with FC have the intestinal flora imbalance, which is related to the disease condition.
作者
刘友迎
龚国忠
代莉
王昌明
程家亮
张孝廉
LIU Youying;GONG Guozhong;DAI Li;WANG Changming;CHENG Jialiang;ZHANG Xiaolian(Clinical Laboratory,Suining Central Hospital,Suining,629000,China;Clinical Laboratory,Suining First People's Hospital)
出处
《中国中西医结合消化杂志》
CAS
2021年第8期580-583,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
功能性便秘
肠道菌群
病情
functional constipation
intestinal flora
disease condition
作者简介
通信作者:龚国忠,E-mail:247684657@qq.com。
