摘要
目的探讨血清尿酸(UA)及胰岛素样生长因子-1(IGF-1)对创伤性脑损伤(TBI)病情及预后的评估价值。方法200例急性TBI患者按入院GCS评分分为重型组(3分~8分,n=34)、中型组(9分~12分,n=45)及轻型组(13分~15分,n=121),选取健康体检者40例作为对照组,均于入院时行血清UA及IGF-1水平检测。患者伤后6个月行格拉斯哥预后(GOS)评分,分为预后不良组(1分~3分)与预后良好组(4分~5分)。结果各伤情TBI组UA水平明显高于对照组(P<0.05),IGF-1水平明显低于对照组(P<0.05);且随着伤情加重,患者UA水平逐渐增高(P<0.05),IGF-1水平逐渐降低(P<0.05)。预后不良组UA水平明显高于预后良好组(P<0.05),IGF-1水平明显低于预后良好组,上述差异均有统计学意义(P<0.05)。UA、IGF-1预测预后不良的ROC曲线下面积分别为0.798、0.959。结论UA、IGF-1表达与TBI患者伤情密切相关,对预后有预测价值。
Objective To explore the value of serum uric acid(UA)and insulin-like growth factor-1(IGF-1)in evaluating the condition and prognosis of traumatic brain injury(TBI).Methods A total of 200 patients with acute TBI were selected and divided into severe group(Score:3-8,n=34),moderate group(Score:9-12,n=45)and mild group(Score:13-15,n=121)according to GCS score at admission.Forty healthy subjects were selected as the control group.All subjects received the measurement of serum UA and IGF-1 at admission,TBI patients were evaluated with GOS score 6 months after injury,and they were divided into poor prognosis group(Score:1-3)and good prognosis group(Score:4-5).Results The UA level in TBI group was significantly higher than that in the control group(P<0.05),and IGF-1 level was significantly lower than that in the control group(P<0.05),with the aggravation of TBI injury,the level of UA in patients increased gradually(P<0.05)and the level of IGF-1 decreased gradually(P<0.05).In the poor prognosis group,the level of serum UA was significantly higher than that in the good prognosis group(P<0.05),and the IGF-1 level was significantly lower than that in the good prognosis,with the differences statistically significant group(P<0.05).The area under the ROC of UA and IGF-1 were 0.798 and 0.959,respectively.Conclusion The expressions of serum UA and IGF-1 are closely related to the injury of TBI patients,which is of great value in predicting the prognosis of patients.
作者
曹朝梁
CAO Chao-liang(Emergency Medicine,Taizhou Central Hospital(Affiliated Hospital of Taizhou University),Taizhou,Zhejiang 318000,China)
出处
《中国卫生检验杂志》
CAS
2021年第14期1761-1763,1766,共4页
Chinese Journal of Health Laboratory Technology
关键词
创伤性脑损伤
尿酸
胰岛素样生长因子-1
预后
Acute traumatic brain injury
Uric acid
Insulin-like growth factor-1
Injury
作者简介
曹朝梁(1981-),男,本科,主治医师,主要从事急诊创伤方面的研究工作。
