摘要
目的 探讨醒脑静联合利巴韦林治疗病毒性脑炎(VE)患儿的疗效。方法 采用随机数字表法将该院2020年12月至2023年2月收治的124例VE患儿分为参照组、研究组,每组62例。参照组在常规治疗的基础上给予利巴韦林治疗,研究组在参照组的基础上给予醒脑静治疗。比较两组临床疗效、症状消失时间、治疗前后神经因子水平[神经生长因子(NGF)、神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)、髓鞘碱性蛋白(MBP)]、血浆细胞参数[辅助性T细胞17(Th17)/调节性T淋巴细胞(Treg)、Treg比例、Th17比例、微小RNA-125b(miR-125b)]、炎症因子水平[转化生长因子-β(TGF-β)、白细胞介素(IL)-17、肿瘤坏死因子-α(TNF-α)、IL-6]和不良反应总发生率。结果 研究组临床总有效率(91.94%)高于参照组(77.42%),差异有统计学意义(P<0.05);治疗后研究组临床症状消失时间均短于参照组(P<0.05);治疗后研究组NGF、MBP、NSE水平低于参照组,BDNF水平高于参照组,差异均有统计学意义(P<0.05);治疗后研究组Th17比例、miR-125b水平和Th17/Treg低于参照组,Treg比例高于参照组,差异均有统计学意义(P<0.05);治疗后研究组TNF-α、IL-6、IL-17水平低于参照组,TGF-β水平高于参照组,差异均有统计学意义(P<0.05);两组不良反应总发生率相比,差异无统计学意义(P>0.05)。结论 醒脑静联合利巴韦林治疗VE的效果显著,能改善患儿神经功能及临床症状,减轻炎症反应,提高免疫功能,用药较安全可靠。
Objective To study the effect of Xingnaojing combined with ribavirin in treating the children patients with viral encephalitis(VE).Methods A total of 124 children patients with VE admitted and treated in this hospital from December 2020 to February 2023 were divided into the reference group and study group according to the random number table method,62 cases in each group.The reference group was treated with ribavirin on the basis of conventional therapy,and the study group was treated with Xingnaojing on the basis of the reference group.The clinical efficacy,symptom disappearance time,neurological factor levels before and after treatment[nerve growth factor(NGF),neuron-specific enolase(NSE),brain-derived neurotrophic factor(BDNF),myelin basic protein(MBP)],plasma cell parameters[helper T cell 17(Th17)/regulatory T cell(Treg),the proportion of Treg,the proportion of Th17,microRNA-125b(miR-125b)]and inflammatory factor levels[transforming growth factor-β(TGF-β),interleukin(IL)-17,tumour necrosis factor-α(TNF-α),IL-6]and the total incidence rate of adverse reactions were compared between the two groups.Results The total clinical efficiency of the study group was higher than that of the reference group(91.94%vs.77.42%,P<0.05),and the difference was statistically significant;the disappearance time of clinical symptoms after treatment in the study group was shorter than that of the reference group(P<0.05);the levels of NGF,MBP and NSE after treatment in the study group were lower than those in the reference group,while BDNF level was higher than that in the reference group,the differences were statistically significant(P<0.05);the proportion of Th17,miR-125b level and Th17/Treg after treatment in the study group were lower than those in the reference group,while the proportion ofTreg was higher than that in the reference group,and the differences were statistically significant(P<0.05).The TNF-α,IL-6 and IL-17 levels after treatment were lower than those in the reference group,while the TGF-βlevel was higher than that in the reference group,and the differences were statistically significant(P<0.05);the total incidence rate of adverse reactions had no statistical difference between the two groups(P>0.05).Conclusion Xingnaojing combined with ribavirin has significant effect in treating VE,could improve the neurological function and clinical symptoms,reduce the inflammatory response,increase the immune function,and the medication safe and reliable.
作者
马金花
MA Jinhua(Department of Pediatrics,Zhumadian Municipal Fourth People′s Hospital,Zhumadian,Henan 463000,China)
出处
《检验医学与临床》
CAS
2024年第1期87-90,94,共5页
Laboratory Medicine and Clinic
作者简介
马金花,女,主治医师,主要从事小儿肺炎、小儿脑炎的诊疗研究。
