摘要
目的探讨卡前列甲酯栓联合催产素对高危产妇剖宫产术后出血的防治效果。方法80例实施剖宫产的高危产妇,将其按照分娩先后顺序分为对照组和研究组,每组40例。对照组在胎儿娩出后宫体肌层注射催产素,研究组剖宫产术中腹膜打开时舌下含服卡前列甲酯栓。比较两组患者出血情况、产后排气情况、血红蛋白、红细胞计数以及不良反应发生情况。结果从出血量情况分析,研究组中有2例产妇总出血量>1000 ml,占比5.0%,对照组中有8例产妇总出血量>1000 ml,占比20.0%,研究组总出血量超过1000 ml的产妇少于对照组;且研究组术中出血量(302.78±178.63)ml、术后2 h出血量(94.14±21.52)ml、术后24 h出血量(308.72±42.48)ml均少于对照组的(429.33±206.46)、(207.23±32.41)、(569.79±43.63)ml,差异具有统计学意义(P<0.05)。研究组中12 h之内排气的产妇多于对照组,24 h之内排气的产妇少于对照组,差异均具有统计学意义(P<0.05)。研究组患者产后血红蛋白(104.34±10.45)g/L、红细胞计数(3.66±0.43)×10^(12)/L高于对照组的(93.23±9.22)g/L、(3.07±0.40)×10^(12)/L,差异均具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对于高危产妇而言,在剖宫产术中应用卡前列甲酯栓联合催产素可以预防术后出血,减少出血量,促进产后排气,而且不会产生严重不良反应,临床价值显著。
Objective To discuss the effect of carboprost methylate suppository combined with oxytocin in the prevention and treatment of postpartum hemorrhage after cesarean section in high-risk parturients.Methods A total of 80 cases of high-risk parturients undergoing cesarean section were divided into control group and research group according to order of delivery,with 40 cases in each group.In the control group,oxytocin was injected into the muscle layer of the uterus after the fetus was delivered.In the research group,carboprost methyl suppository was administered sublingually when the peritoneum was opened during cesarean section.The bleeding,postpartum exhaust,hemoglobin,red blood cell count,and the occurrence of adverse reactions were compared between the two groups.Results In the research group,there were 2 parturients with total blood loss>1000 ml,accounting for 5.0%.In the control group,there were 8 parturients with total blood loss>1000 ml,accounting for 20.0%.The number of parturients with total blood loss>1000 ml in the research group was less than that of the control group.The intraoperative blood loss(302.78±178.63)ml,blood loss 2 h after operation(94.14±21.52)ml and blood loss 24 h after operation(308.72±42.48)ml of the research group were less than(429.33±206.46),(207.23±32.41)and(569.79±43.63)ml of the control group,and the difference was statistically significant(P<0.05).The research group had fewer women with postpartum exhaust within 12 h than that of the control group,and fewer women with postpartum exhaust within 24 h than that of the control group,and the difference was statistically significant(P<0.05).The postpartum hemoglobin(104.34±10.45)g/L and red blood cell count(3.66±0.43)×10^(12)/L of the research group were higher than(93.23±9.22)g/L and(3.07±0.40)×10^(12)/L of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion For high-risk parturients,the application of carboprost methylate suppository and oxytocin during cesarean section can prevent postoperative hemorrhage,reduce amount of bleeding,and promote postpartum exhaust,without serious adverse reactions,and has significant clinical value.
作者
耿兴玲
GENG Xing-ling(Tengzhou Maternal and Child Health Hospital,Zaozhuang 277500,China)
出处
《中国现代药物应用》
2021年第15期177-179,共3页
Chinese Journal of Modern Drug Application
关键词
卡前列甲酯栓
催产素
高危产妇
剖宫产
术后出血
Carboprost methylate suppository
Oxytocin
High-risk parturients
Cesarean section
Postpartum hemorrhage
