摘要
卵巢癌是妇科恶性肿瘤之一,由于其早期症状不典型,确诊时往往已达疾病晚期,成为威胁女性健康的一大杀手。现代研究发现,肿瘤细胞与其周围微环境共同进化是导致卵巢癌发生、发展的重要原因。中医学认为,阴阳是一切事物的根本,阴阳平衡是机体健康的标志,即"阴平阳秘"状态,阴阳的对立制约、互根互用、消长与转化是维持阴阳平衡的关键。卵巢癌在中医学中属"癥瘕""积聚""肠蕈"范畴,其发生、发展是正气与邪气抗争,正虚邪盛,阴阳失衡的结果。而机体与卵巢癌炎性微环境,以及炎性微环境中的相关因子也处于对立制约、相互转化的状态,表现出动态发展的"阴阳"关系,二者高度契合。目前,中医药对于卵巢癌炎性微环境的研究多从信号通路传导角度出发,体现出多成分多靶点对癌细胞的作用优势,未能从中医阴阳平衡角度阐释其意义。因此,笔者以"阴阳平衡观"为切入点,从宏观及微观角度探讨卵巢癌炎性微环境中相关因子的改变对卵巢癌发生、发展产生的影响,论述其与中医理论的高度契合性,以此为基础提出"调整阴阳平衡"为卵巢癌的防治原则,扶正与祛邪兼顾,以期为中医理论阐释卵巢癌炎性微环境的现代研究中奠定基础,以及在中西医结合指导卵巢癌的临床治疗中提供理论依据。
Ovarian cancer,one of gynecological malignancies,is often diagnosed at the late stage because of the atypical early symptoms and has become a major killer of women. Research has found that the coevolution of tumor cells and their surrounding microenvironment is an important cause for the occurrence and development of ovarian cancer. It is believed in traditional Chinese medicine(TCM)that Yin and Yang are the roots of everything,and their balance,namely Yin being at peace and Yang being compact("Yin Ping Yang Mi")is a sign of good health. The mutual opposition,restriction,and rooting of Yin and Yang as well as their waning and waxing and transformation are the keys to maintaining the balance. In TCM,ovarian cancer falls into the category of abdominal mass,which results from the struggle between healthy Qi and evil Qi. When the healthy Qi is deficient and the evil Qi is excessive,the balance between Yin and Yang will be destroyed,triggering the body and ovarian cancer microenvironment as well as the relevant factors in the inflammatory microenvironment to be mutually opposed,restricted,and transformed,highly consistent with the dynamic development of Yin and Yang. At present, the studies concerning TCM intervention in the inflammatory microenvironment of ovarian cancer mostly focus on the signaling pathways to reveal the advantages of TCM multiple components against cancer cells via multiple targets,but they fail to explain the TCM efficacy from the perspective of Yin-Yang balance. Therefore, guided by the concept of Yin-Yang balance, this paper macroscopically and microscopically explored the effects of the changed factors in inflammatory microenvironment on the occurrence and development of ovarian cancer,and put forward that the prevention and control principles of ovarian cancer should lie in the "adjustment of Yin-Yang balance",accompanied by healthy Qi reinforcement and pathogen elimination. This paper has laid the foundation for the elucidation of modern research achievements regarding the ovarian cancer microenvironment with TCM theory and provide a theoretical basis for the clinical treatment of ovarian cancer with integrated TCM and western medicine.
作者
王玮玉
郭滢
沈影
杨爽
韩凤娟
WANG Wei-yu;GUO Ying;SHEN Ying;YANG Shuang;HAN Feng-juan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第12期237-244,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(82074484)
黑龙江省自然科学基金项目(ZD2018020)
黑龙江中医药大学科研基金项目(2019BS07)。
关键词
卵巢癌
炎性微环境
阴阳平衡
ovarian cancer
inflammatory microenvironment
Yin-Yang balance
作者简介
第一作者:王玮玉,在读博士,从事中西医结合治疗妇科肿瘤的临床研究,E-mail:wang452638182@qq.com;通信作者:韩凤娟,教授,主任医师,博士生导师,从事中西医结合治疗妇科肿瘤的临床研究,Tel:0451-82111401,E-mail:hanfengjuan2004@163.com。
