摘要
circRNA作为ceRNA中的一员,能够竞争性结合microRNA(miRNA),解除miRNA对目标mRNA的抑制作用,进而调控肿瘤的发生发展。化疗是肿瘤治疗的重要手段之一,尤其对于晚期恶性肿瘤,化疗具有至关重要的地位。然而大多数肿瘤在化疗过程中不可避免的出现耐药,这严重影响了肿瘤的治疗效果和患者的预后,攻克肿瘤耐药迫在眉睫。越来越多研究发现circRNAs能够调控肿瘤耐药。为了更好的了解circRNAs在化疗耐药方面的作用,下面就有关circRNAs在肿瘤耐药方面的研究进行归纳总结,希望能为攻克肿瘤耐药提供新的思路和研究方向,使更多肿瘤患者能够从中获益。
circRNA,as a member of ceRNA,can competitively combine with microRNA(miRNA)and remove the inhibition of miRNA on target mRNA,which plays an important regulatory role in the occurrence and development of carcinoma.Chemotherapy is one of the important means of cancer treatment,in particularly,chemotherapy plays a vital role in advanced malignant tumors.However,chemoresistance is inevitable in most carcinoma during chemotherapy,which seriously affects the therapeutic effect and prognosis.Therefore,it is urgent to conquer chemoresistance of cancer.There are increasing studies that circRNAs can regulate carcinoma chemoreisetance.In order to better understand the function of circRNAs in chemotherapy resistance,the following is a summarization of the research about circRNAs in tumor drug resistance,and to provide new ideas and research directions for overcoming tumor drug resistance,so that more cancer patients can benefit from it.
作者
赖明芬
梅家转
朱俊林
黄甘萍
芦青青
LAI Mingfen;MEI Jiazhuan;ZHU Junlin;HUANG Ganping;LU Qingqing(The Second School of Clinical Medicine,Southern Medical University,Guangdong Guangzhou 510280,China;Zhengzhou People's Hospital,Southern Medical University,Henan Zhengzhou 450003,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第9期1639-1642,共4页
Journal of Modern Oncology
作者简介
赖明芬(1991-),女,广东人,硕士,主要从事非编码RNA在肿瘤防治方面的研究,E-mail:2496419817@qq.com;通讯作者:梅家转(1966-),男,河南新野人,主任医师,博士,主要从事肿瘤分子靶向治疗研究,E-mail:mjzhuan@163.com。
