摘要
肿瘤耐药是由药物靶标改变、细胞内部药物浓度下降等引起的复杂过程。尽管新型化疗药物的设计正在迅速发展,但对于晚期肿瘤(如侵袭和转移)尚无有效的化疗药物。肿瘤细胞对药物的耐药性受多种因素影响,如个体遗传差异、肿瘤微环境、肿瘤干细胞、药物失活、药物吸收减少、药物代谢改变、药物靶点基因突变、肿瘤免疫系统改变等。本文介绍了目前主要的肿瘤耐药发生机制以及肿瘤对常见抗肿瘤药物耐药的原因,并从不同角度总结解决肿瘤耐药性的策略。
Cancer drug resistance is a complex process caused by changes in drug targets and the concentration reduction in the cells and so on.Although the design of new chemotherapeutic drugs is evolving rapidly,effective chemotherapeutic drugs have not been found for advanced cancers such as invasion and metastasis.Resistance of cancer cells to therapeutic agents is influenced by a number of factors,such as genetic differences among different tumor microenvironment,tumor stem cells,drugs inactivation,drug absorption deduction,anti-cancer drug metabolism alteration,target gene mutation and tumor immune system changes.In this review,we highlight the current major cancer drug resistance mechanisms and the failure of common therapy drugs in different types of cancer,and summary the main solutions to the problem.
作者
李芳
蒋妮谚含
柳文洁
程泽能
LI Fang;JIANG Niyanhan;LIU Wenjie;CHENG Zeneng(Department of Biopharmacy,Xiangya Pharmacy Sciences,Changsha,Hunan,410013,China)
出处
《肿瘤药学》
CAS
2018年第3期307-312,共6页
Anti-Tumor Pharmacy
基金
国家自然科学基金资助项目(No.81503023)
作者简介
李芳,女,硕士研究生,研究方向:创新药物体外药代动力学与生物药剂学研究,E-mail:15084849285@163.com。;通讯作者:柳文洁,女,硕士研究生导师,研究方向:新型喷雾干燥技术与药物临床代谢动力学,E-mail:wenjie.liu@csu.edu.cn。
