摘要
脾位于中焦,主运化,为气血生化之源。膏脂由脾运化水谷所生,中土得运,纳运有常,则膏脂可随血循环以濡养五脏六腑及四肢百骸;肝脏是脂质代谢重要的器官,其参与脂质消化、吸收、转运等功能,脾气健运,肝失疏泄,肝脏脂质代谢功能与"脾"运化功能相关。肝细胞自噬是维持肝脏脂质代谢稳态的关键因素之一,自噬功能正常则肝脏脂质代谢趋于平衡。本文基于脾与脂质相关性,从"脾主运化"探讨肝细胞自噬对脂质代谢的影响及机制。
The spleen, located in the middle Jiao, is the source of energy and blood biochemistry. The lipid is produced by the spleen transporting and transforming water and valleys."Zhong Tu, e.g the spleen"is regulated and then nutrients can be absorbed and transported normally, so the lipid can circulate with the blood to nourish the internal organs and the limbs;the liver is an important organ for lipid metabolism, which participates in lipid digestion, absorption, and transportation. Spleen qi, liver failure, and liver lipid metabolism are related to the transportation and chemical functions of the spleen. Hepatocyte autophagy is one of the key factors to maintain the homeostasis of liver lipid metabolism. If the autophagy function is normal, liver lipid metabolism tends to be balanced. Based on the correlation between the spleen and lipids, this article explores the effect and mechanism of hepatocyte autophagy on lipid metabolism from the perspective of"the spleen has the function of digesting food, absorbing water and grain essence and transferring it to the whole body".
作者
冷雪
王莹
李阳
宋囡
贾连群
Leng Xue;Wang Ying;Li Yang;Song Nan;Jia Lianqun(Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Centre for Innovative Engineering Technology in Traditional Chinese Medicine,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Animal Center in Traditional Chinese Medicine,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第1期58-62,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81774022):基于TMA/FMO3/TMAO通路探讨肠道微生物组对脾失健运膏脂转输障碍的影响及机制,负责人:贾连群
辽宁省科学技术厅博士启动基金(2020-BS-166):基于LncXIST/miR-182/FOXO1介导的HDL代谢探讨香砂六君子汤对脾失健运膏脂转输障碍的影响及机制,负责人:冷雪。
关键词
脾主运化
细胞自噬
脂质代谢
肝脏
Spleen governing transportation and transformation
Cell autophagy
Fat metabolism
Liver
作者简介
通讯作者:贾连群,博士,教授,博士研究生导师,主要研究方向:中西医结合防治心血管疾病。
