摘要
目的探究慢性阻塞性肺疾病急性加重期(AECOPD)患者幽门螺杆菌(Helicobacter pylori,Hp)的感染现状及其对肺功能、凝血功能的影响。方法选取2018年1月-2019年12月在合肥市滨湖医院就诊的112例AECOPD患者为研究组,采用14C呼气试验检测Hp感染情况,根据是否存在Hp感染分为Hp感染组和Hp未感染组,另选取112例同期慢性阻塞性肺疾病(COPD)患者为对照组。分析两组和研究组内Hp感染与Hp未感染患者凝血功能、肺功能指标和APACHEⅡ评分的差异。结果 AECOPD组患者凝血功能指标中血浆纤维蛋白原(FIB)和D二聚体(DD)均高于对照组,抗凝血酶原Ⅲ(AT-Ⅲ)低于对照组(P<0.05);肺功能指标第1秒钟用力呼气容积(FEV1)、用力肺活量(FVC)和FEV1/FVC均低于对照组(P<0.05);112例AECOPD患者中Hp感染阳性68例,感染率为60.71%;Hp感染组APACHEⅡ评分高于Hp未感染组;凝血功能指标血浆FIB和DD高于未感染组,AT-Ⅲ低于未感染组(P<0.05);肺功能指标FEV1、FVC和FEV1/FVC低于未感染组(P<0.05)。结论 AECOPD组患者Hp感染阳性率较高,合并Hp感染可以加重AECOPD患者的肺功能和凝血功能障碍,推进疾病的恶性进展。
OBJECTIVE To investigate the current status of Helicobacter pylori(Hp)infection in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and observe its impact on pulmonary function,and coagulation function.METHODS Totally 112 patients with AECOPD who were treated in Hefei Binhu Hospital from Jan 2018 to Dec 2019 were assigned as the study group and were divided into the Hp infection group and the non-Hp infection group according to the results of 14 C breath test,meanwhile,112 patients with COPD were set as the control group.The coagulation function,pulmonary function indexes and APACHEⅡscore were observed and compared between the study group and the control group as well as between the Hp infection group and the non-Hp infection group.RESULTS The levels of coagulation function indexes plasma fibrinogen(FIB)and D-dimer(DD)of the study group were higher than those of the control group,while the anti-prothrombin III(AT-Ⅲ)of the study group was significantly lower than that of the control group(P<0.05).The forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and FEV1/FVC of the study group were significantly lower than those of the control group(P<0.05).Among the 112 AECOPD patients,68 were tested positive for Hp,with the infection rate 60.71%.APACHEⅡscore of the Hp infection group was significantly higher than that of the non-Hp infection group;the levels of coagulation function indexes plasma FIB and DD of the infection group were significantly higher than those of the non-infection group(P<0.05);the pulmonary function indexes FEV1,FVC and FEV1/FVC of the infection group were significantly lower than those of the non-infection group(P<0.05).CONCLUSION The positive rate of Hp infection of the AECOPD patients is high,the complication with Hp infection may aggravate the pulmonary and coagulation function dysfunction,and promote the malignant progression of disease.
作者
胡承志
孟令毅
潘爱军
丁斌
宋志友
鲍勇
陈春燕
HU Cheng-zhi;MENG Ling-yi;PAN Ai-jun;DING Bin;SONG Zhi-you;BAO Yong;CHEN Chun-yan(Hefei Binhu Hospital,Hefei,Anhui 2300009 China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2021年第1期68-72,共5页
Chinese Journal of Nosocomiology
基金
安徽省科技计划基金资助项目(1808085MH300)。
关键词
慢性阻塞性肺疾病
幽门螺杆菌
凝血功能
Chronic obstructive pulmonary disease
Helicobacter pylori
Coagulation function
作者简介
胡承志(1974-),男,研究生,副主任医师,研究方向:急诊医学;通讯作者:陈春燕,E-mail:13955173180@139.com。
