摘要
能量代谢重编程是肿瘤的重要特征之一,是通过上调有氧糖酵解代谢,抑制氧化磷酸化反应造成胃黏膜上皮细胞代谢失衡,促使炎症微环境向肿瘤微环境转化的特征效应,在慢性萎缩性胃炎“炎-癌”转化过程中发挥关键作用。本文主要从能量代谢与氧化应激、线粒体损伤、微环境形成、免疫抑制的关系等方面归纳了代谢重编程在慢性萎缩性胃炎进展为胃癌的分子机制研究进展。从而提出了调节异常能量代谢可以有效降低氧化应激损伤,改善微环境,以延缓恶化时间,截断炎癌转化的进程。
Reprogramming of energy metabolism is one of the important characteristics of cancer.It is a characteristic effect of up-regulating aerobic glycolysis metabolism and inhibiting oxidative phosphorylation to cause metabolic imbalance of gastric mucosal epithelial cells and promote the transformation of inflammatory microenvironment to tumor microenvironment,which plays a key role in the"inflammation-cancer"transformation of chronic atrophic gastritis.This article summarizes the research progress of the molecular mechanism of metabolic reprogramming in the progression of chronic atrophic gastritis to gastric cancer from the relationship between energy metabolism and oxidative stress,mitochondrial damage,microenvironment formation,and immunosuppression.Therefore,it is proposed that the regulation of abnormal energy metabolism can effectively reduce oxidative stress damage,improve microenvironment,delay the deterioration time,and cut off the process of inflammatory to cancer transformation.
作者
刘亚
徐文倩
郭敏
LIU Ya;XU Wenqian;GUO Min(The First Clinical Medical College of Henan University of Chinese Medicine,Henan Zhengzhou 450000,China;Spleen,Stomach,Hepatobiliary Department,the First Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450000,China)
出处
《现代肿瘤医学》
CAS
2024年第8期1567-1572,共6页
Journal of Modern Oncology
基金
河南省2022年度省级科技研发计划联合基金(编号:豫科项[2022]52号)。
关键词
能量代谢重编程
慢性萎缩性胃炎
“炎-癌”转化
reprogramming of energy metabolism
chronic atrophic gastritis
"inflammation to cancer"transformation
作者简介
刘亚(1999-),女,河南信阳人,硕士研究生在读,主要从事中医防治消化系统疾病研究。E-mail:1054180258@qq.com;通信作者:郭敏(1982-),女,河北临城人,副主任医师,博士后,硕士生导师,主要从事中西医结合防治消化系统疾病研究。E-mail:hbguomin@sina.com。
