摘要
溃疡性结肠炎(ulcerative colitis,UC)为1种病因不明且易反复发作的慢性非特异性肠道疾病,由环境因素、遗传、肠道微生物失调、粘膜和上皮屏障功能异常以及免疫失调等因素所致.其临床症状主要为腹痛、腹泻、黏液脓血便等.治疗药物主要以氨基水杨酸类、皮质类固醇、免疫抑制剂等为主,但这些药物可能有不同的副作用,甚至严重的不良反应,中药具有安全系数高、毒副作用少等优点,而起作用的主要为其有效成分.综述概括了中药有效成分通过6种信号通路(TLR4/MyD88/NF-κB、NLRP3、PPARγ/NF-κB、MAPK、Treg/Th17、JAK2/STAT3)治疗溃疡性结肠炎的研究进展,为中药开发以及其对溃疡性结肠炎的机制研究提供了新的思路.
Caused by multiple factors such as environmental factors, heredity, intestinal microbiological disorders, mucosal and epithelial barrier dysfunctions and immune disorders, ulcerative colitis(UC) is a recurrent, chronic non-specific intestinal inflammatory disease whose etiology is not very clear. UC patients have the clinical symptoms such as abdominal pain, diarrhea, tenesmus, mucus, pus and blood in the stool, etc. The main therapeutic drugs are the aminosalicylic acid, corticosteroids, immunosuppressive agents, etc. However, these drugs may have different side effects and even serious adverse reactions. Traditional Chinese medicine has long been used in treating UC with the advantages of a higher safety level and less side effects. Therefore, this review summarizes the research progress of traditional Chinese medicine on UC through six main signaling pathways(TLR4/MyD88/NF-κB, NLRP3, PPARγ/NF-κB, MAPK, Treg/Th17, JAK2/STAT3) in order to provide new ideas for the development of traditional Chinese medicine and clarify its mechanism on ulcerative colitis.
作者
李婷
邹秋萍
何红平
王亭
黄丰
李艳平
LI Ting;ZOU Qiu-ping;HE Hong-ping;WANG Ting;HUANG Feng;LI Yan-ping(School of Chinese Medicine,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China)
出处
《云南民族大学学报（自然科学版）》
CAS
2020年第6期541-548,共8页
Journal of Yunnan Minzu University:Natural Sciences Edition
基金
国家自然科学基金(81960777,81660717,31760100,81760745)
云南省应用基础研究项目(2019FF002(-005),2017FB133)
云南省教育厅科学研究基金(2019Y0332)。
关键词
溃疡性结肠炎
中药有效成分
信号通路
ulcerative colitis
active constituents of traditional Chinese medicine
signaling pathway
作者简介
李婷(1996-),女,硕士研究生,主要研究方向:天然药物化学成分及生物活性研究;通信作者:李艳平(1986-),女,博士,副教授,硕士生导师,主要研究方向:中药、天然药物化学成分及生物活性研究.
