摘要
NLRP3(NLR family pyrin domain containing 3)炎症小体作为炎症反应的核心,其过度激活参与了多种疾病的发生,包括引发神经退行性疾病、自身免疫疾病和代谢紊乱性疾病等。近年来研究发现来源于天然化合物的多种黄酮类成分能广泛防治NLRP3炎症小体过度激活引发的疾病,其机制与抵抗氧化应激,促进自噬,稳定线粒体功能,调节离子通道及抑制NLRP3炎症小体组成等多种途径有关。本文归纳整理了NLRP3炎症小体过度激活引发的疾病类型与发病机制,并总结了黄酮类成分抑制NLRP3炎症小体激活的作用机制及防治多种疾病的最新研究报道,以期为黄酮类成分应用于防治NLRP3炎症小体相关疾病的研发提供新思路。
NLRP3(NLR family pyrin domain containing 3)is the core of the inflammatory response,and its excessive activation involves the development of various diseases,including neurodegenerative diseases,autoimmune diseases and metabolic disorders,etc.In recent years,it has been found that natural flavonoids can extensively inhibit the diseases caused by NLRP3 inflammation overactivation via various mechanisms,including resistance to oxidative stress,promotion of autophagy,stabilization of mitochondrial function,adjustment ion channels and inhibition of NLRP3 inflammation composition.In this paper,we reviewed the relevant latest research reports,compiled the types and pathogenesis of diseases caused by excessive activation of NLRP3 inflammation,and summarized the mechanisms on the prevention and treatment of various diseases by inhibiting NLRP3 inflammation with natural flavonoids.This review provides new ideas for the development of new drugs using flavonoid components in the prevention and treatment of NLRP3 inflammatory-related diseases.
作者
张学艳
黄必胜
李娟
Zhang Xueyan;Huang Bisheng;Li Juan(College of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第11期3523-3532,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会青年基金(81903921):江南卷柏黄酮调控NLRP3炎症小体抑制细胞焦亡治疗痛风的作用机制,负责人:李娟
作者简介
通讯作者:李娟,教授,主要研究方向:中药资源及活性评价。
