摘要
溃疡性结肠炎(UC)是一种病因不明的直肠和结肠炎性疾病,临床表现为反复发作的腹泻、腹痛及黏液脓血便,又称为非特异性溃疡性结肠炎。选择合适的动物模型有助于进行UC的机制及治疗研究。UC造模方法众多,但因为模型制备手段、发病机制、持续时间等各不相同,文章就常用的葡聚糖硫酸钠(DSS)模型、三硝基苯磺酸(TNBS)-乙醇模型及免疫复合TNBS-乙醇模型进行介绍对比,以期为动物模型的合适选择及继续完善提供新思路。
Ulcerative colitis(UC)is an unknown cause of rectal and colitis disease whose clinical manifestations are recurrent diarrhea,abdominal pain and mucus pus blood stool.And it is also known as non-specific ulcerative colitis.A suitable animal model can help us in the treatment and mechanism study of UC.There are many ways to build a model of UC,but because the method of model preparation,the pathogenesis,the duration and so on are all different.This paper introduces and compares three kinds of models:sodium dextran sulfate model,TNBS-ethanol model and immune compound TNBS-ethanol model,in order to provide new ideas for the proper selection and further improvement of animal models.
作者
焦文超
罗慧
苏聪平
王青
石冰洁
郭淑贞
JIAO Wen-chao;LUO Hui;SU Cong-ping;WANG Qing;SHI Bing-jie;GUO Shu-zhen(Beijing University of Chinese Medicine,Beijing 102488,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第11期5821-5823,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点研发计划项目(No.2017YFC1700105)。
关键词
溃疡性结肠炎
动物模型
三硝基苯磺酸
葡聚糖硫酸钠
Ulcerative colitis
Animal models
Trinitrobenzene sulfonic acid
Dextran sulfate sodium
作者简介
通信作者:郭淑贞,北京市房山区良乡镇阳光南大街与白杨东路交叉路口东北角北京中医药大学(良乡校区)中医学院邮编:102488,电话:010-53912009,E-mail:guoshz@bucm.edu.cn。
