摘要
目的对比研究DSS、TNBS、OXZ诱导的结肠炎动物模型。方法本研究选取了一般状态、DAI评分和组织学损伤评分几个方面来评价。结果 DSS组大鼠造模安全性较高,在整个实验过程中无大鼠出现死亡,而TNBS组及OXZ组均有2只大鼠出现死亡,DSS组大鼠DAI评分升高较快,于实验第7天时各模型组DAI评分差异无统计学意义,TNBS组组织学损伤最重,但各造模组之间差异无统计学意义。结论三种造模方法均可以成功诱导大鼠实验性结肠炎模型,各造模组DAI评分和组织学损伤没有显著的差异。DSS造模方法具有较高的安全性。
Objective To compare the colitis aninal models induced by DSS, TNBS or OXZ. Methods This study selected several aspects of rats such as the general state, DAI score, and histological injury for evaluation. Results The rat model safety was higher in the DSS group with no death in the whole experiment process, two rats died in the TNBS group and OXZ group, respectively. DAI score rising of the DSS group was faster, but had no prominent differ- ence in all model group in the seventh day of the experiment, the histological injury of the TNBS group was the most se- rious, but no prominent difference was available among all model groups. Conclusion Three model methods can suc- cessfully induce rat experimental colitis models, DAI score and histological injury have no prominent differences. DSS modeling method has high safety.
出处
《胃肠病学和肝病学杂志》
CAS
2013年第12期1221-1224,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
沈阳市科技资助项目(f12-277-1-54)
