摘要
目的:检测不同恶性肿瘤患者血浆D-二聚体(D-dimer,D-D)和纤维蛋白原(fibrinogen,Fbg)含量及抗凝血酶Ⅲ(antithrombinⅢ,AT-Ⅲ)活性,探讨其对于恶性肿瘤患者诊断的临床价值。方法:由法国STAGO公司的全自动凝血分析仪测定265例恶性肿瘤患者血浆D-D,AT-Ⅲ活性,F b g含量并进行比较,同时选择100例健康体检者作为正常对照组。结果:恶性肿瘤患者血浆D-D和Fbg含量升高,与正常对照组比较差异有统计学意义(P<0.05),AT-Ⅲ活性显著低于正常对照组(P<0.05)。结论:通过检测患者D-D,AT-Ⅲ活性,Fbg含量有助于恶性肿瘤的辅助诊断,具有临床应用价值。
Objective:To investigate the clinical value of plasma D-dimer,fibrinogen,and antithrombinⅢactivity in patients with malignant tumor.Methods:The densities of plasma D-dimer,antithrombinⅢactivity,fibrinogen were detected in the 265 patients with malignant tumors.And 100 healthy cases were selected as a normal control group.The detecting instrument was Automatic Coagulation Analyzer of STAGO company(France).Results:Compared with the normal control group,the levels of plasma D-dimer and fibrinogen in patients with malignant tumors were significantly increased(P<0.05),antithrombinⅢactivity was significantly lower than that of the normal control group(P<0.05).Conclusion:The detection of D-dimer,antithrombinⅢactivity,and fibrinogen is helpful for the auxiliary diagnosis of malignant tumor.
作者
金萍
王亚萍
孙兵
龚芳
卢志贤
JIN Ping;WANG Yaping;SUN Bing;GONG Fang;LU Zhixian(Department of Laboratory,Affiliated Hospital of Jiangnan University,Wuxi Jiangsu 214041,China;Department of Laboratory,63680 Army Hospital,Jiangsu Jiangyin 214400,China)
出处
《临床与病理杂志》
2020年第10期2534-2537,共4页
Journal of Clinical and Pathological Research
基金
江苏省“333”人才资助项目(BRA2019152)。
作者简介
通信作者:卢志贤,Email:seed001lzx@163.com。
