摘要
目的对肝癌患者的纤维蛋白原(Fib)和D-二聚体(D-dimer)进行检测,了解纤维蛋白原和D-二聚体与肝癌转移的关系,并评价其在肝癌辅助诊断的临床意义。方法取200例肝癌患者、30例对照组(健康体检者)的静脉血,采用乳胶凝集半定量法测定血浆D-dimer,采用全自动血凝仪检测Fib含量。结果200例肝癌患者中,肿瘤初治组和难治转移组的血浆D-dimer及Fib含量明显升高,治疗缓解组血浆D-dimer及Fib含量有不同程度下降。结论Fib及D-dimer含量的变化,与肝癌病情严重程度及预后显著相关。其检测方法简便、快速、敏感性高,可作为肝癌的辅助诊断及预后判断的一项早期诊断参考指标。
Objective To observe the relevance of plasma D-dimer and fibrinogen in hepatocellular carcinoma. Methods From 200 hcpatocellular carcinoma patients and 30 normal adults, plasma D-dimer levels and fibrinogen levels were measurad by Latex Agglutinative test(LAT), and semiautomatic coagulometer, respectively. Results Plasma D-dimer and fibrinogen levels in the primary therapy group were higher than that in the normal adults group, however they showed downtrend in the catabatic group. Conclusion Measure plasma D-dimer and fibrinogen levels could be a predictor in tumor patient.
出处
《分子诊断与治疗杂志》
2009年第2期108-110,共3页
Journal of Molecular Diagnostics and Therapy
关键词
肝癌
纤维蛋白原
D-二聚体
预后
Hepatocellular carcinoma
Fibrinogen
D-dimer
Prognosis
