摘要
目的:观察荆芥连翘汤加减从肺论治溃疡性结肠炎的效果,分析其对肠黏膜屏障功能、免疫调节、氧化应激指标的影响。方法:将80例溃疡性结肠炎患者按照随机数字表法分为对照组和观察组,每组各40例,对照组患者予以美沙拉嗪肠溶片,观察组患者则在此基础上加用荆芥连翘汤加减内服治之,两周为1个疗程,连续治疗4个疗程。测定肠黏膜屏障功能、免疫调节、氧化应激指标变化,评价用药的有效性和安全性。结果:观察组有效率90.00%(36/40),与对照组的有效率70.00%(29/40)的相比明显升高(χ^2=5.000,P<0.05);治疗后,两组患者的肠黏膜屏障功能均有所改善,D-乳酸、内毒素、DAO水平显著低于治疗前(P<0.05),以观察组明显低于对照组(P<0.05);观察组患者治疗后患者治疗后TNF-α、IL-8、β-EP含量显著低于对照组,IL-2含量显著高于对照组(P<0.05);治疗后,观察组治疗后的SOD水平显著高于对照组,MAD、LPO水平显著低于对照组(P<0.05);治疗过程中,观察组与对照组患者的不良反应发生率分别为5.00%、15.00%,但差异无统计学意义(χ^2=2.222,P>0.05)。结论:荆芥连翘汤加减内服从肺论治溃疡性结肠炎的效果满意,利于保护肠黏膜屏障,初步分析可能与纠正机体的免疫状态及降低肠黏膜氧化应激水平有关。
Objective:To observe the effect of nepeta forsythia decoction on ulcerative colitis,and to analyze its effect on intestinal mucosal barrier function,immune regulation and oxidative stress.Methods:80 patients with ulcerative colitis were divided into the control group and the observation group with 40 cases each according to the random number table method.Patients in the control group were given mesalazine enteric-dissolution tablets,while patients in the observation group were treated with nepeta forsythia decoction plus internal administration.The changes of intestinal mucosal barrier function,immune regulation and oxidative stress were measured,and the efficacy and safety of the drug were evaluated.Results:The effective rate in the observation group was 90.00%(36/40),which was significantly higher than that in the control group of 70.00%(29/40)(χ^2=5.000,P<0.05).After treatment,the intestinal mucosal barrier function of patients in both groups was improved,and the levels of d-lactic acid,endotoxin and DAO were significantly lower than before treatment(P<0.05),so that the observation group was significantly lower than the control group(P<0.05).After treatment,the contents of TNF-,IL-8 andβ-EP in the observation group were significantly lower than those in the control group,and the contents of IL-2 were significantly higher than those in the control group(P<0.05).After treatment,SOD level in the observation group was significantly higher than that in the control group,and MAD and LPO levels were significantly lower than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions was 5.00%in the observation group and 15.00%in the control group,but the difference was not statistically significant(χ^2=2.222,P>0.05).Conclusion:The effect of nepeta forsythia decoction on ulcerative colitis is satisfactory,which is conducive to protecting the intestinal mucosal barrier.Preliminary analysis of the mechanism of its effect may be related to correcting the immune state of the body and reducing the level of intestinal mucosal oxidative stress.
作者
白鹏飞
张艳君
李敏
BAI Pengfei;ZHANG Yanjun;LI Min(Department of Spleen and Stomach,Tangshan Traditional Chinese Medicine Hospital in Hebei Province,Tangshan 063000)
出处
《陕西中医》
2020年第7期897-900,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
河北省中医药管理局科研课题(2014262)。
关键词
溃疡性结肠炎
荆芥连翘汤
从肺论治
肠膜屏障功能
免疫调节
氧化应激指标
Ulcerative colitis
Nepeta forsythia soup
Treatment from lung
Intestinal mucosal barrier function
Immune regulation
Oxidative stress index
