摘要
目的比较非肌层浸润性膀胱癌(NMIBC)采用两种经尿道膀胱肿瘤电切术(TURBT)治疗的效果及预后。方法回顾性选取2015年2月至2018年2月德阳市人民医院泌尿外科收治的NMIBC患者150例,依据所行TURBT术式不同分为观察组、对照组。观察组(n=45)采用经尿道钬激光切除术(HOLTUR),对照组(n=105)采用经尿道双极等离子电切术(TURIS)。比较两组围术期指标、术后复发率、并发症发生率。结果观察组单发肿瘤手术时间、术后膀胱冲洗时间、肉眼血尿时间、导尿管留置时间、住院时间短于对照组,观察组术中出血量低于对照组(P<0.05),两组多发肿瘤手术时间比较差异无统计学意义(P>0.05);术后6个月、12个月观察组复发率明显低于对照组(P<0.05),两组术后3个月复发率比较差异无统计学意义(P>0.05);观察组术后6个月内闭孔神经反射、膀胱穿孔发生率低于对照组(P<0.05),两组低钠血症、尿道狭窄、输尿管口狭窄发生率比较差异无统计学意义(P>0.05)。结论与TURIS术相比,HOLTUR术治疗NMIBC有创伤小、手术时间短、术后恢复快、复发率及并发症发生率低等优点,值得在临床推广实践。
Objective To compare the curative effects and prognosis of two kinds of transurethral resection of bladder tumor(TURBT)for non-muscle invasive bladder carcinoma(NMIBC).Methods A total of 150 NMIBC patients admitted to the Department of Urology in Deyang People'Hospital from February 2015 to February 2018 were enrolled.They were divided into observation group and control group according to different TURBT procedures.The observation group(n=45)was given holmium laser transurethra resection(HOLTUR),while the control group(n=105)was given bipolar transurethral resection in saline(TURIS).The perioperative indexes,postoperative recurrence rate and incidence of complication in both groups were recorded.Results The operation time of single tumor,postoperative bladder irrigation time,macroscopic hematuria time,indwelling time of urinary catheter and hospitalization time in the observation group were shorter than those in the control group.The intraoperative blood loss was lower than that in the control group(P<0.05).There was no significant difference in the operation time of multiple tumors between the two groups(P>0.05).The recurrence rates of the observation group were significantly lower than those of the control group at 6 months and 12 months after operation(P<0.05).There was no significant difference in recurrence rate between the two groups at 3 months after operation(P>0.05).The incidence rates of obturator nerve reflex and bladder perforation in the observation group were lower than those in the control group within 6 months after operation(P<0.05).There was no significant difference in the incidence of hyponatremia,urethral stenosis or ureteral orifice stenosis between the two groups(P>0.05).Conclusion Compared with TURIS,HOLTUR has the advantages for NMIBC such as less trauma,shorter operation time,faster postoperative recovery,low incidence of recurrence and complications.
作者
段晓波
代庆德
周婷婷
DUAN Xiao-bo;DAI Qing-de;ZHOU Ting-ting(Department of Urology,Deyang People's Hospital,Deyang Sichuan 618000,China;Fujian Medical University,Fuzhou Fujian 350004,China.)
出处
《临床和实验医学杂志》
2020年第12期1322-1325,共4页
Journal of Clinical and Experimental Medicine
基金
四川省卫生计划委员会资助项目(编号:150247)。
作者简介
通讯作者:周婷婷,E-mail:363910555@qq.com。
