摘要
目的探讨钬激光肿瘤切除术(HOLRBT)对非肌层浸润性膀胱癌(NMIBC)患者的治疗效果。方法选取2018年1月至2020年6月在郑州人民医院接受微创手术治疗的118例NMIBC作为研究对象,根据术式分为观察组(59例)和对照组(59例),对照组患者接受经尿道肿瘤电切除术(TURBT)治疗,观察组患者接受HOLRBT治疗。对两组患者手术情况指标、血清肿瘤因子指标、手术并发症以及疾病复发进行评价。结果观察组患者手术出血量少于对照组,手术时长、置管时间和术后住院时间短于对照组,差异有统计学意义(P<0.05);术后3 d,两组患者血清肿瘤特异性生长因子(TSGF)、血管内皮生长因子(VEGF)均有降低,并且观察组血清肿瘤因子水平均低于对照组,差异有统计学意义(P<0.05);观察组手术并发症发生率(3.39%)低于对照组(15.25%),1 a内疾病复发率(5.08%)低于对照组(16.95%),差异有统计学意义(P<0.05)。结论HOLRBT可改善NMIBC患者手术相关指标,减少并发症的发生,并能够有效抑制术后血清肿瘤因子的分泌,降低疾病复发风险。
Objective To explore the treatment effect of transurethral resection of bladder tumor(TURBT)and holmium laser resection of bladder tumor(HOLRBT)for patients with non-muscular invasive bladder cancerc(NMIBC).Methods A total of 118 patients with NMIBC underwent minimally invasive surgery in Zhengzhou People’s Hospital from January 2018 to June 2020 were selected as the research object,and the patients were divided into observation group(59 cases)and control group(59 cases)according to the surgical approach.Patients in the control group were treated with transurethral resection of bladder tumor(TURBT),and patients in the observation group were treated with HOLRBT.Surgical indicators,serum tumor factors,surgical complications,and disease recurrence of the two groups were evaluated.Results The blood loss in the observation group was lower than the control group,and the surgical indicators of operation time,catheter placement time and postoperative hospital stay were lower than the control group(P<0.05).The serum levels of tumor-specific growth factor(TSGF)and vascular endothelial growth factor(VEGF)in the two groups were decreased 3 days after operation,and the serum tumor factors in the observation group were lower than the control group(P<0.05).The incidence of surgical complications(3.39%)in the observation group was lower than the control group(15.25%),and the disease recurrence rate within 1 year(5.08%)was lower than the control group(16.95%)(P<0.05).Conclusion HOLRBT could improve the surgical indicators,reduce the occurrence of complications,effectively inhibit the secretion of serum tumor factors after surgery,and reduce the risk of disease recurrence for patients with NMIBC.
作者
翟晓磊
ZHAI Xiaolei(Department of Urology,Zhengzhou People’s Hospital,Zhengzhou 450003,China)
出处
《河南医学研究》
CAS
2021年第35期6609-6612,共4页
Henan Medical Research
关键词
经尿道钬激光切除术
经尿道肿瘤电切除术
非肌层浸润性膀胱癌
transurethral resection of bladder tumor
transurethral holmium laser resection of bladder tumor
non-muscular invasive bladder cancer
