摘要
目的分析血清甘胆酸(cholyglycine,CG)和铜蓝蛋白(ceruloplasmin,CP)在成人肝硬化进展过程中的水平变化,以及联合检测CG和CP对肝硬化患者评估肝细胞损害程度的应用价值。方法随机选择2018年9月至2019年9月入我院确诊为肝硬化患者共60例,其中代偿期40例和失代偿期20例,另选择肝纤维化患者35例、乙型肝炎患者35例和健康体检者35例;分别检测各组治疗前后及健康体检者当日血清CG和CP、白蛋白(ALB)、丙氨酸氨基转移酶(ALT)和谷草转氨酶(AST)、炎症因子IL-6和TNF-α水平,最后根据受试者工作曲线(ROC)分析联合检测血清CG和CP诊断肝硬化的准确性。结果治疗前血清CG、ALT、AST、IL-6和TNF-α水平,在健康体检者、乙型肝炎、肝纤维化、肝硬化代偿期和失代偿期患者中逐渐升高,而CP和ALB水平逐渐下降(P<0.05)。除了健康体检组,其他各组患者治疗后血清CG、ALT、AST、IL-6和TNF-α水平均比治疗前降低,CP和ALB水平升高(P<0.05)。经ROC分析发现,联合检测血清CG和CP评估肝硬化的准确性为0.854。结论血清CG和CP水平变化对反映肝硬化的不同进展阶段有重要的评估价值,可能成为重要的诊断标志物。
Objective To analyze the changes of serum Cholyglycine(CG)and ceruloplasmin(CP)in the development of adult cirrhosis,and the value of combined detection of CG and CP in evaluating degrees of liver cell damage in patients with cirrhosis.Methods A total of 60 patients with liver cirrhosis from September,2018 to September,2019 were randomly selected for the study,including 40 patients with compensatory period and 20 patients with decompensated period.In addition,35 patients with liver fibrosis,35 patients with hepatitis B and 35 healthy people were chosen at the same time.We then detected serum CG and CP,ALT,AST,IL-6 and TNF-αlevels before and after the treatment.The accuracy of serum CG and CP detection by ROC analysis for the diagnosis of cirrhosis was measured.Results Compared with healthy people,levels of serum CG,ALT,AST,IL-6 and TNF-αin hepatitis B patients increased before the treatment,while serum CP levels decreased;Compared with hepatitis B patients,levels of serum CG,ALT,AST,IL-6 and TNF-αin liver fibrosis patients increased before the treatment,and serum CP level decreased;Compared with liver fibrosis patients,levels of serum CG,ALT,AST,IL-6 and TNF-αin patients with liver cirrhosis in compensatory period before the treatment increased and CP level decreased;Compared with compensatory period patients,levels of serum CG,ALT,AST,IL-6 and TNF-αin decompensation patients before the treatment increased and CP level decreased(all P<0.05).Except for the healthy people group,levels of serum CG,ALT,AST,IL-6 and TNF-αin other groups after the treatment were lower than before,and CP level was higher(P<0.05).ROC analysis showed that the accuracy of combined detection of serum CG and CP was 0.854.Conclusion The changes of serum CG and CP levels have important evaluation values in reflecting different stages of cirrhosis,and could serve as the important diagnostic markers.
作者
段丽
DUAN Li(Reproduction Center, Chenzhou Municipal First People′s Hospital, Chenzhou 423000,China)
出处
《标记免疫分析与临床》
CAS
2020年第4期653-657,共5页
Labeled Immunoassays and Clinical Medicine
关键词
甘胆酸
铜蓝蛋白
肝硬化
肝纤维化
乙型肝炎
Cholyglycine
Ceruloplasmin
Cirrhosis
Liver fibrosis
Hepatitis B
