摘要
目的研究乙肝肝硬化及乙肝相关性肝癌(以下简称肝癌)患者血清铜蓝蛋白(Cp)含量变化,探讨Cp在肝癌发生中的作用。方法选取符合纳排标准的乙肝肝硬化组患者60例、肝癌组患者90例,另选取同期健康体检者30例作为对照组。采用免疫散射比浊法测定各组患者Cp含量,比较各组水平的差异。结果乙肝肝硬化组、肝癌组患者Cp水平与对照组间比较差异有统计学意义(F=53.620,P<0.05);肝癌组与肝硬化代偿期组比较,早期肝癌组Cp水平差异无统计学意义,中、晚期组Cp水平显著升高差异具有统计学意义(P<0.05);肝癌组与肝硬化失代偿期组比较,早、中、晚期肝癌组Cp水平均显著升高差异具有统计学意义(P<0.05),且Cp含量随着临床分期的增高而升高。Cp、甲胎蛋白(AFP)单独诊断ROC曲线下面积分别为(0.788、0.799)差异有统计学意义(P<0.05),Cp联合AFP诊断ROC曲线下面积增大为0.848(P<0.05)。结论血清Cp水平的升高可能与肝癌病情发展相关,Cp可作为肝病诊断的重要参考指标,对判断肝癌患者诊断、疗效及预后具有潜在的价值。
Objective To study the chance of serum ceruloplasmin（Cp） in patients with HBV - related Cirrhosis and HBV - related Hepatocellu - lar Carcinoma （HCC） . To investigate the effect of Cp in the pathogenesis of HCC. Methods A cohort of 150 pa- tients with HBV - associated liver disease were divided into two groups ： liver cirrhosis without HCC group （ including 60cases） ; HCC group（ including 90cases）. A further 30 healthy individuals comprised the healthy control group. The level of Serum Cp were measured by immunological scatting turbidity method, the results were statistically analyzed. Results The levels of serum Cp in compensated cirrho- sis, decompensated cirrhosis and control group respectively, and its level decreased gradually with the aggravated of disease. Among the three groups, the differences between every two groups was statistical significant （ P 〈 0. 05 ）. Compared with compensated cirrhosis, the level of serum Cp in early liver cancer was reduced, but the difference was not statistically significant. The level of mid and late liver cancer was increase, the difference were statistically significantly （P 〈 0. 05）. Compared with decompensated cirrhosis, the level of Cp in early, middle and late stage of liver cancer increased along with the level of clinical stage among the four groups and the differences between every two groups were statistical significant （P 〈 0. 05 ）. To detecting the Cp in cirrhosis and hepatocellular carcinoma group, the ROC curve of Cp and AFP in diagnosis of liver cancer were 0. 788 and 0. 799 respectively, with diagnostic significance respectively （ P 〈 0.05 ）, The ROC curve of Cp, AFP joint diagnosis was 0. 848, with diagnostic significance （ P 〈 0.05 ）. Conclusion Serum Cer- uloplasmin has a potential value in the diagnosis, curative effect and prognostic for HCC patients.
出处
《宁夏医学杂志》
CAS
2018年第2期105-108,共4页
Ningxia Medical Journal
关键词
血清铜蓝蛋白
乙肝肝硬化
乙肝相关性肝癌
Serum copper - blue protein
HBV - related cirrhosis
HBV - related hepatocellu - carcinoma
作者简介
【通讯作者】张栩，Email：xvzhang@163.com
