摘要
目的探讨晚期非小细胞肺癌放射治疗联合靶向治疗的应用及预后。方法方便选取该院2013年1月-2014年1月收治的100例晚期非小细胞肺癌患者,随机分为两组,各50例,尼妥珠单抗靶向联合放疗组给予尼妥珠单抗靶向联合放射治疗,常规放疗方案治疗组采用常规放疗方案,对比两组晚期非小细胞肺癌患者的总缓解率和疾病控制率、1年内生存率及EORTC生命质量测定量表QLQ-C30 (V30)评分、信号通路分子(包括MAPK、ERK1、ERK2、AKT、PI13K、JAK2、STAT3)MRNA水平。结果尼妥珠单抗靶向联合放疗组总缓解率48.00%明显高于常规放疗方案治疗组36.00%,对比差异有统计学意义(χ~2=8.168,P<0.05),总控制率88.00%明显高于常规放疗方案治疗组76.00%,对比差异有统计学意义(χ~2=8.158,P<0.05)。尼妥珠单抗靶向联合放疗组1年内生存率84.00%高于常规放疗方案治疗组52.00%(χ~2=5.924,P<0.05)。结论采用尼妥珠单抗治疗晚期非小细胞肺癌具有良好的治疗效果。
Objective To investigate the application and prognosis of radiotherapy combined with targeted therapy for advanced non-small cell lung cancer. Methods Convenient selection of 100 patients with advanced non-small cell lung cancer admitted to the hospital from January 2013 to January 2014 were randomly divided into two groups, 50 patients each,and nimotuzumab targeted radiotherapy group was given nimotuzin. Anti-targeted combined radiotherapy, conventional radiotherapy regimen used conventional radiotherapy to compare the overall remission rate and disease control rate, one-year survival rate and EORTC quality of life measurement scale QLQ-C30 in two groups of patients with advanced nonsmall cell lung cancer(V30) Score, MNA levels of signaling pathway molecules(including MAPK, ERK1, ERK2, AKT,PI13 K, JAK2, STAT3). Results The total remission rate of the nimotuzumab-targeted radiotherapy group was 48.00% higher than that of the conventional radiotherapy group(36.00%). The difference was statistically significant(χ~2=8.168, P<0.05), and the total control rate 88.00%. was higher than the conventional radiotherapy regimen, 76.00% of the treatment groups and the difference was statistically significant(χ~2=8.158, P <0.05). The survival rate of the nimotuzumab-targeted combined radiotherapy group was 84.00% within one year compared with that of the conventional radiotherapy group 52.00%(χ~2=5.924, P<0.05). Conclusion Nimotuzumab has a good therapeutic effect in the treatment of advanced non-small cell lung cancer.
作者
王芳
刘贵宝
王作胜
张秀秀
滕丽娜
赵增强
WANG Fang;LIU Gui-bao;WANG Zuo-sheng;ZHANG Xiu-xiu;TENG Li-na;ZHAO Zeng-qiang(Department of oncolohy,Rizhao City Center Hospital,Rizhao,Shandong Province,276800 China)
出处
《中外医疗》
2020年第5期17-19,共3页
China & Foreign Medical Treatment
关键词
晚期非小细胞肺癌
放射治疗
靶向治疗
应用预后
Advanced non-small cell lung cancer
Radiotherapy
Targeted therapy
Applied prognosis
作者简介
王芳(1980-),女,山东济宁人,硕士,主治医师,研究方向:常见肿瘤的放化疗及靶向治疗。
