摘要
目的分析探究晚期非小细胞肺癌靶向治疗后的失败模式及联合放疗临床意义。方法取云南省红河州第三人民医院2020年接受治疗晚期非小细胞肺癌患者20例,将其分观察组与对照组,每组10例,对照组采用靶向治疗方案与放疗模式,观察组采用同步放化疗靶向治疗模式,比较两组患者的治疗效果、不良反应发生状况、生活质量评分统计,分析失败模式的临床影响。结果①两组患者治疗效果对比:观察组患者治疗效果总有效率高于对照组,两组患者对比有统计学差异(P<0.05)。②两组患者不良反应发生情况对比:不良反应发生率低于对照组,两组患者对比有统计学差异(P<0.05)。③生活质量评分对比:生活质量评分统计结果均优于对照组,两组患者对比有统计学差异(P<0.05)。④观察组失败模式发生时间低于对照组,数据对比差异有统计学意义(P<0.05)。结论失败模式分为快速、局部发展、缓慢进展,晚期非小细胞肺癌患者采用同步放化疗靶向治疗模式在临床上有重要意义,可以取得显著效果,安全性高,值得推广应用于临床治疗中。
Objective To analyze the failure mode of targeted therapy for advanced non-small cell lung cancer(NSCLC)and its clinical significance.Methods Twenty patients with advanced non-small cell lung cancer in the Third People’s Hospital of Honghe Prefecture in 2020 were divided into observation group and control group,with 10 cases in each group.The control group was treated with targeted therapy and radiotherapy mode,and the observation group was treated with concurrent chemoradiotherapy targeted therapy mode,the clinical effect of failure mode was analyzed.Results①Comparison of the treatment effect between the two groups of patients:The total effective rate of the treatment effect of the observation group was higher than that of the control group,and there was a statistical difference between the two groups of patients(P<0.05).②Comparison of the incidence of adverse reactions between the two groups of patients:The incidence of adverse reactions was lower than that of the control group,and there was a statistical difference between the two groups of patients(P<0.05).③Comparison of quality of life scores:The statistical results of quality of life scores were better than those of the control group,and there was a statistical difference between the two groups of patients(P<0.05).④The failure mode of the observation group occurred less time than the control group,and the difference in data comparison was statistically significant(P<0.05).Conclusion The failure mode can be divided into rapid,local development and slow progress.It is of great clinical significance for patients with advanced non-small cell lung cancer to adopt concurrent chemoradiotherapy targeted treatment mode,which can achieve significant effect and high safety,and is worthy of promotion and application in clinical treatment.
作者
孙黎
SUN Li(Department of Radiation Oncology,the Third People’s Hospital of Honghe Prefecture,Gejiu,Yunnan 661000)
出处
《智慧健康》
2021年第19期97-99,共3页
Smart Healthcare
关键词
晚期非小细胞肺癌
靶向治疗
联合放疗
临床意义
Advanced non-small cell lung cancer
Targeted therapy
Combined radiotherapy
Clinical significance
